| Background | c Kit, also known as CD117 and stem cell factor receptor, is a 145 kDa transmembrane tyrosine kinase encoded by the c Kit proto oncogene. c Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. Mutations in c Kit have been found to be important for tumor growth and progression in a variety of cancers including mast cell diseases, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma and lung cancer. Phosphorylation at tyrosines 568 and 570 of c Kit allows binding and activation of Src family kinases. |
| Synonyms | CKit, KIT, CD117, P10721, SCFR, C-Kit, PBT, 164920, 3815, c Kit, c-Kit (phospho Y568/Y570), c-Kit (phospho Tyr568/Tyr570), c-Kit (pY568/pY570), c-Kit (pTyr568/pTyr570), c-Kit phospho Y568/Y570, c-Kit phospho Tyr568/Tyr570, Phospho c-Kit (Y568/Y570), Phosp |