|Full Name||protein kinase, cGMP-dependent, type I|
|Product Description||Rabbit Polyclonal antibody to cGK1 (protein kinase, cGMP-dependent, type I)|
|Background||Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity. [provided by RefSeq, Sep 2011]|
|Synonyms||CGKI antibody, cGK1 alpha antibody, DKFZp686K042 antibody, FLJ36117 antibody, MGC71944 antibody, PGK antibody, PKG antibody, PRKG1B antibody, PRKGR1B antibody, cGKI-BETA antibody, cGKI-alpha antibody, PRKG1 antibody, protein kinase, cGMP-dependent, regulatory, type I, beta antibody, cGMP-dependent protein kinase 1 antibody, protein kinase, cGMP-dependent, type I antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human cGK1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Rat, Japanese medaka, Pig, Rabbit, Bovine|
|Predict Reactivity Note||Human (100%), Rat (99%), Japanese medaka (84%), Pig (99%), Rabbit (98%), Bovine (99%)|