Product Name
Alpha-Synuclein antibody
Catalog Number
GTX74280
Product Description:
Goat polyclonal to Alpha - Synuclein
Application Note:
For IHC-P: Use at a dilution of 1:300. For ELISA: Use at a dilution of 1:1,000 vs immunising peptide. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher.
Background:
Alpha Synuclein is implicated in the regulation of dopamine release and transport. It is a soluble protein, expressed principally in the brain but also expressed in low concentrations in all tissues examined (except liver). In the nervous system, alpha Synuclein is primarily located at presynaptic terminals and is found membrane bound in dopaminergic neurons. It can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies), including Parkinson's Disease. Alpha Synuclein induces fibrillization of microtubule associated protein tau and reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase 3 activation. Alpha synuclein is a protein phosphorylated predominantly on serine residues.
Cross Reactivity:
Human and goat - not yet tested in other species
Purity:
Unpurified
Storage Instruction:
Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.
Concentration:
antiserum
Storage Buffer:
Antiserum containing 0.09% sodium azide
Target Protein:
Human alpha-synuclein
Purification Note:
From polyclonal serum
Clonality:
Polyclonal
Epitope:
Not yet determined
Tested Applications:
ELISA, IHC (Formalin-fixed paraffin-embedded sections). The usefulness of this product in other applications has not been determined.
Positive Control:
Brain, Spinal cord
Form:
Liquid
Specificity:
Recognizes human alpha-synuclein. The alpha-synuclein gene, located on chromosome 4, has been linked to early onset autosomal dominant Parkinson's disease. The protein is abundant in the nervous system, and is known to be the precursor of the non-beta amyloid component protein (NACP) of Alzheimer's disease. Alpha-synuclein has also been found to be associated with other neurodegenerative diseases such as multiple system atrophy and dementia with Lewy's bodies.
Immunogen:
Synthetic peptide corresponding to amino acids 116-131 of the C-terminus of a synuclein
Host:
Goat
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