Product Name
AKT peptide-phospho T308 (phospho and non-phospho pair)
Catalog Number
GTX25319
Product Description:
AKT peptide - phospho T308 ( phospho and non - phospho pair )
Background:
Phosphorylation site specific antibody selective for the phosphorylated form of the AKT protein containing a phosphate on threonine 308. The antibody has been shown to recognize AKT in NIH-3T3 cells stimulated with PDGF. AKT is a key effector of the PI3K pathway. Several studies have shown that a signalling pathway from PI3K to AKT may mediate some cellular responses of PI3K, including protection from apoptosis in PC12 cells. AKT accomplishes its cell survival-promoting function by inhibiting apoptosis by means of its ability to phosphorylate and inactivate BAD and caspase 9. The function of AKT is regulated by phosphorylation on two sites conserved within the AGC kinase family: the activation loop (threonine 308) in the kinase core and hydrophobic phosphorylation site on the carboxyl terminus (serine 473). Threonine 308 is phosphorylated by the phosphoinositide-dependent kinase 1 (PDK 1).
Storage Buffer:
Lyophilized powder with trifluoroacetate salt.
Cellular Localization:
Cytoplasmic and Nuclear after activation by integrin linked protein kinase 1 (ILK1).
Target Protein:
AKT
Purification Note:
GTX25319P - >90% by HPLC analysis (purity based on peak area). GTX25319N - >85% by HPLC analysis (purity based on peak area).
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