Product Name
ACE2 peptide (788-805)
Catalog Number
GTX15352
Product Description:
ACE2 peptide (788-805)
Application Note:
For BL: Use at an assay dependent dilution. The peptide is used for blocking the activity of ACE2 antibody. It usually blocks the antibody activity completely in Western blot by incubating the peptide with equal volume of antibody for 30 min at 37°C. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Background:
Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently ACE2 has also been shown to be a functional receptor of the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.
Sequence:
Synthetic peptide corresponding to C terminal amino acids 788-805 of Human ACE2.
Tested Applications:
Blocking. The usefulness of this product in other applications has not been determined.
Target Protein:
ACE2
Form:
Liquid
Concentration:
0.2 mg/ml
Storage Buffer:
Phosphate-buffered saline, pH 7.2, containing 0.1% BSA and 0.02% Sodium azide
Storage Instruction:
Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.
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