Product Name
ATF4 phospho S245 antibody
Catalog Number
GTX48830
Product Description:
Rabbit polyclonal to ATF4 (phospho S245)
Application Note:
IHC-P: 1/50 - 1/100. Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Tested Application:
IHC (Formalin-fixed paraffin-embedded sections). The usefulness of this product in other applications has not been determined.
Background:
ATF4 is a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain (referenced from Entrez gene).
Clonality:
Polyclonal
Specificity:
ATF4 (phospho-Ser245) antibody detects endogenous levels of ATF4 only when phosphorylated at serine 245.
Immunogen:
The antiserum was produced against synthesized phosphopeptide derived from human ATF4 around the phosphorylation site of serine 245 (N-R-S^P-L-P).
Host:
Rabbit
Isotype:
IgG
Cross-Reactivity:
Human - Not yet tested in other species
Positive Control:
Breast carcinoma
Target Protein:
ATF4 phospho S245
Cellular Localization:
Nuclear
Form:
Liquid
Concentration:
1 mg/ml
Purity:
Affinity purified with antigen
Storage Buffer:
Phosphate buffered saline, pH 7.3, 50% glycerol and 150mM NaCl containing 0.02% sodium azide
Storage:
Upon Receipt - Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.
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