Product Name
Ku80 [149.8] antibody
Catalog Number
GTX70276
Product Description:
Mouse monoclonal antibody to human Ku80
Manufacturer & Mfg Part#:
GeneTex GTX70276
Application Note:
For WB: Use at a dilution of 1:1,000. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher.
:
Store at -80 °C. Avoid repeat freeze-thaw cycles.
Background:
Originally identified as an autoantigen, the Ku protein are nuclear proteins found in eukaryotes. They exist as a heterodimer consisiting of Ku 70 and Ku 80, migrating at approximately 70 and 80 kDa respectively. They bind to DNA ends at double strand breaks. The Ku proteins interact with the DNA-dependent protein kinase (DNA-PK) and participate in the targeting of DNA-PK to DNA. The Ku proteins may participate in numerous cellular processes, including DNA repair and replication, cell signalling, cell proliferation, transcriptional activation and apoptosis.
Target Protein MW:
80
Purity:
Protein G Affinity Purified
Expression system:
pQE
Myeloma:
NS1
Concentration:
1 mg/ml
Clone Number:
149.8
Storage Buffer:
Phosphate-buffered saline, pH 7.4, containing no preservatives
Cross-Reactivity:
Human - Not yet tested in other species
Target Protein:
Ku80
Purification Note:
From ascitic fluid
Clonality:
Monoclonal
Tested Applications:
Western blot. The usefulness of this product in other applications has not been determined.
Positive Control:
HeLa, Raji
Form:
Liquid
Isotype:
IgG
Immunogen:
Recombinant antigen containing the carboxy terminal portion of human Ku80 protein
Host:
Mouse
Storage:
Store at -80 °C. Avoid repeat freeze-thaw cycles.
General References:
1. Weaver, D. T. Trends Genetics. 11:388-392 (1995
1995
7482764
2. Jackson, S.P. Curr. Opinion Gen. and Dev. 6:19-25 (1996).
1996
8791484
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