Product Name
FANCD2 (Fanconi anemia D2) antibody [103]
Catalog Number
GTX70299
Product Description:
Mouse Monoclonal to human FANCD2 ( Fanconi anemia D2 ) Antibody [Clone 103]
Manufacturer & Mfg Part#:
GeneTex GTX70299
Application Note:
1:500 - 1:100. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher.
Background:
Fanconi Anemia Complementation Group D2 (FANCD2) protein is one of at least six factors shown to be involved in the autosomal-recessive cancer-prone disorder, Fanconi Anemia (FA). FA group D has been shown to be comprised of two separate proteins, FANCD1 and FANCD2. Mutations in BRCA2 can cause FANCD1. FANCD2 has been shown to colocalize with BRCA1 in ionizing radiation-induced foci. FANCD2 is involved in genomic resistance to DNA cross-linking reagents, and the arrest of DNA synthesis following exposure to ionizing radiation. FANCD2 has been shown to directly interact with NBS1
Purity:
Protein G affinity purified
Expression system:
pGEX-3X
Myeloma:
NS1
Concentration:
1 mg/ml
Clone Number:
103
Storage Buffer:
Phosphate-buffered saline, pH 7.2, containing no preservatives
Cellular Localization:
Nuclear
Cross-Reactivity:
Human - Not yet tested in other species
Target Protein:
FANCD2
Purification Note:
From mouse ascitic fluid.
Clonality:
Monoclonal
Tested Applications:
ELISA, Western blot. The usefulness of this product in other applications has not been determined.
Form:
Liquid
Isotype:
IgG
Immunogen:
Human FANCD2 fusion protein
Host:
Mouse
Storage:
For long term storage, please keep at -70°C or below. Avoid repeared freeze-thaw cycles.
General References:
1. Timmers, C et al. Molec. Cell 7: 241-248, 2001
2001
11239453
2. Garcia-Higuera, I., et al. Molec. Cell 7: 249-262, 2001.
2001
11239454
3. Nakanishi, K., et al. Nature Cell Biol. 4: 913-920, 2002
2002
12447395
4. Strathdee, C. A. et al. Nature Genet. 1: 196-198, 1992.
1992
1303234
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