|Full Name||eukaryotic translation initiation factor 3, subunit E|
|Product Description||Rabbit Polyclonal antibody to eIF3e (eukaryotic translation initiation factor 3, subunit E)|
|Background||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins. |
|Synonyms||EIF3-P48 antibody, EIF3S6 antibody, INT6 antibody, eIF3-p46 antibody, EIF3E antibody, murine mammary tumor integration site 6 (oncogene homolog) antibody, eIF-3 p48 antibody, eukaryotic translation initiation factor 3 subunit 6 antibody, viral integration site protein INT-6 homolog antibody, mammary tumor-associated protein INT6 antibody, eukaryotic translation initiation factor 3, subunit 6 (48kD) antibody, eukaryotic translation initiation factor 3, subunit 6 48kDa antibody, eukaryotic translation initiation factor 3 subunit E antibody, eukaryotic translation initiation factor 3, subunit E antibody|
|Cellular Localization||Cytoplasm , Nucleus |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human eIF3e. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Chicken, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Chicken (96%), Rhesus Monkey (100%), Bovine (100%)|