|Full Name||eukaryotic translation initiation factor 4E|
|Product Description||Rabbit Polyclonal antibody to eIF4E (eukaryotic translation initiation factor 4E)|
|Background||All eukaryotic cellular mRNAs are blocked at their 5-prime ends with the 7-methylguanosine cap structure, m7GpppX (where X is any nucleotide). This structure is involved in several cellular processes including enhanced translational efficiency, splicing, mRNA stability, and RNA nuclear export. EIF4E is a eukaryotic translation initiation factor involved in directing ribosomes to the cap structure of mRNAs. It is a 24-kD polypeptide that exists as both a free form and as part of a multiprotein complex termed EIF4F. The EIF4E polypeptide is the rate-limiting component of the eukaryotic translation apparatus and is involved in the mRNA-ribosome binding step of eukaryotic protein synthesis. The other subunits of EIF4F are a 50-kD polypeptide, termed EIF4A (see MIM 601102), that possesses ATPase and RNA helicase activities, and a 220-kD polypeptide, EIF4G (MIM 600495) (Rychlik et al., 1987 [PubMed 3469651]).[supplied by OMIM]|
|Synonyms||AUTS19 Antibody , EIF4E1 Antibody , EIF4EL1 Antibody , EIF4E Antibody , EIF4F Antibody , eukaryotic translation initiation factor 4E Antibody , CBP Antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human eIF4E. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Rabbit, Rhesus Monkey, Chimpanzee, Bovine|
|Predict Reactivity Note||Rat (99%), Rabbit (99%), Rhesus Monkey (100%), Chimpanzee (100%), Bovine (99%)|