|Full Name||polypyrimidine tract binding protein 1|
|Product Description||Rabbit Polyclonal antibody to hnRNP 1 (polypyrimidine tract-binding protein 1)|
|Background||This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq]|
|Synonyms||HNRNP-I antibody, HNRNPI antibody, HNRPI antibody, MGC10830 antibody, MGC8461 antibody, PTB antibody, PTB-1 antibody, PTB-T antibody, PTB2 antibody, PTB3 antibody, PTB4 antibody, pPTB antibody, PTBP1 antibody, 57 kDa RNA-binding protein PPTB-1 antibody, RNA-binding protein antibody, hnRNP I antibody, heterogeneous nuclear ribonucleoprotein I antibody, polypyrimidine tract-binding protein 1 antibody, polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoprotein I) antibody, heterogeneous nuclear ribonucleoprotein polypeptide I antibody, polypyrimidine tract binding protein 1 antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human hnRNP 1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Japanese medaka, Xenopus laevis, Pig, Chicken, Bovine|
|Predict Reactivity Note||Mouse (95%), Rat (95%), Japanese medaka (82%), Xenopus laevis (91%), Pig (96%), Chicken (94%), Bovine (94%)|