|Full Name||heterogeneous nuclear ribonucleoprotein A1|
|Product Description||Rabbit Polyclonal antibody to hnRNP A1 (heterogeneous nuclear ribonucleoprotein A1)|
|Background||This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is one of the most abundant core proteins of hnRNP complexes and it is localized to the nucleoplasm. This protein, along with other hnRNP proteins, is exported from the nucleus, probably bound to mRNA, and is immediately re-imported. Its M9 domain acts as both a nuclear localization and nuclear export signal. The encoded protein is involved in the packaging of pre-mRNA into hnRNP particles, transport of poly A+ mRNA from the nucleus to the cytoplasm, and may modulate splice site selection. It is also thought have a primary role in the formation of specific myometrial protein species in parturition. Multiple alternatively spliced transcript variants have been found for this gene but only two transcripts are fully described. These variants have multiple alternative transcription initiation sites and multiple polyA sites. [provided by RefSeq]|
|Synonyms||HNRPA1 antibody, MGC102835 antibody, hnRNP A1 antibody, hnRNP-A1 antibody, HNRNPA1 antibody, hnRNP core protein A1-like 3 antibody, hnRNP A1-like 3 antibody, single-strand RNA-binding protein antibody, heterogeneous nuclear ribonucleoprotein A1 antibody, Putative heterogeneous nuclear ribonucleoprotein A1-like 3 antibody, single-strand DNA-binding protein UP1 antibody, heterogeneous nuclear ribonucleoprotein B2 protein antibody, helix-destabilizing protein antibody, heterogeneous nuclear ribonucleoprotein A1B protein antibody, nuclear ribonucleoprotein particle A1 protein antibody, heterogeneous nuclear ribonucleoprotein core protein A1 antibody, hnRNP core protein A1 antibody|
|Cellular Localization||Nucleus , Cytoplasm |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human hnRNP A1. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Xenopus laevis, Pig, Chicken, Rhesus Monkey, Chimpanzee, Bovine|
|Predict Reactivity Note||Xenopus laevis (92%), Pig (100%), Chicken (97%), Rhesus Monkey (98%), Chimpanzee (100%), Bovine (100%)|