mTOR antibody [GT649]
Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Positive Controls||Jurkat , Raji , NCI-H929 , 293T , A431 , HeLa , HepG2|
(Please refer to the vial label for the specific concentration)|
|Purification||Affinity purified by Protein G.|
|Full Name||mechanistic target of rapamycin (serine/threonine kinase)|
|Product Description||Mouse Monoclonal antibody [GT649] to mTOR (mechanistic target of rapamycin (serine/threonine kinase))|
|Background||The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq]|
|Synonyms||RAPT1 Antibody, FRAP Antibody, mechanistic target of rapamycin (serine/threonine kinase) Antibody, FRAP2 Antibody, MTOR Antibody, FRAP1 Antibody, RAFT1 Antibody|
|Cellular Localization||Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side , Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side , Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side |
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human mTOR. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Zebrafish, Sheep|
|Predict Reactivity Note||Rat (99%), Zebrafish (90%), Sheep (98%)|