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1 .GTX132803 mTOR (phospho Ser2448) antibody

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mTOR (phospho Ser2448) antibody

Biological & Orthogonal

  • Host / ClonalityRabbit Polyclonal
  • ApplicationsIHC-P, WB
  • Species reactivityHuman, Mouse
  • Publication  ( 1 )
Cat No: GTX132803
Package Price Qty
25 μlUSD 119.00
100 μlUSD 319.00
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  • Anti-mTOR (phospho Ser2448) antibody used in Western Blot (WB). GTX132803
  • Anti-mTOR (phospho Ser2448) antibody used in Western Blot (WB). GTX132803
  • Anti-mTOR (phospho Ser2448) antibody used in IHC (Formalin-fixed paraffin-embedded sections). GTX132803
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  • Bio-info
  • Protocol & MSDS
  • Application Information: mTOR (phospho Ser2448) antibody

Catalog Number GTX132803
☆☆☆☆☆
( 0 )
Publication ( 1 )
Product Name mTOR (phospho Ser2448) antibody
See all mTOR products
ApplicationsIHC-P, WB
Application Note
Suggested dilutionReference
IHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000*  
Western Blot (WB)1:500-1:3000* Y
Not tested in other applications.
*Optimal dilutions/concentrations should be determined by the researcher.
Predicted Target Size289 kDa (note)
Positive ControlsNIH-3T3 (starvation for 16 hr) , NIH-3T3 (starvation for 16 hr and 200 ng/ml EGF treatment for 0.5 hr) , 293T , 293T (200 ng/ml EGF treatment for 0.5 hr)
Form SuppliedLiquid
Concentration0.31 mg/ml (Please refer to the vial label for the specific concentration)
PurificationPurified by antigen-affinity chromatography.

  • Specifications: mTOR (phospho Ser2448) antibody

Full Namemechanistic target of rapamycin (serine/threonine kinase)
BackgroundThe protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq]
Cellular LocalizationEndoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side , Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side , Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side
HostRabbit
ClonalityPolyclonal
IsotypeIgG
ImmunogenCarrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human mTOR (phospho Ser2448). The exact sequence is proprietary.
Antigen SpeciesHuman
Species ReactivityHuman, Mouse
Predicted Cross Reactivity species Predicted cross-reactivity:
    Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
    Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
Rat, Sheep
Predict Reactivity NoteRat (100%), Sheep (100%)
ConjugationUnconjugated

  • Storage Conditions: mTOR (phospho Ser2448) antibody

Storage Buffer1XPBS, 1% BSA, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.
Storage InstructionKeep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
NotesFor In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
ResearchArea
  • Cancer > Type of cancer > Head and Neck > Esophageal
  • Cancer > Type of cancer > Prostate cancer
  • Disease Related > Alzheimer's disease
  • Disease Related > Cardiovascular > Heart > Heart disease
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mTOR (phospho Ser2448) antibody validated data
  • Anti-mTOR (phospho Ser2448) antibody used in Western Blot (WB). GTX132803
    • GTX132803 WB Image
      Untreated (–) and treated (+) NIH-3T3 whole cell extracts (30 µg) were separated by 5% SDS-PAGE, and the membrane was blotted with mTOR (phospho Ser2448) antibody (GTX132803) diluted at 1:1000. The signal was developed with Trident ECL plus-Enhanced.
      Top
  • Anti-mTOR (phospho Ser2448) antibody used in Western Blot (WB). GTX132803
    • GTX132803 WB Image
      Untreated (–) and treated (+) 293T whole cell extracts (60 µg) were separated by 5% SDS-PAGE, and the membrane was blotted with mTOR (phospho Ser2448) antibody (GTX132803) diluted at 1:1000.
      Top
  • Anti-mTOR (phospho Ser2448) antibody used in IHC (Formalin-fixed paraffin-embedded sections). GTX132803
    • GTX132803 IHC-P Image
      mTOR (phospho Ser2448) antibody detects mTOR (phospho Ser2448) protein at cytoplasm by immunohistochemical analysis in the presence of control peptide (left) or antigen-specific peptide (right).
      Sample: Paraffin-embedded human lung cancer.
      mTOR (phospho Ser2448) stained by mTOR (phospho Ser2448) antibody (GTX132803) diluted at 1:500.
      Top
  • Anti-mTOR (phospho Ser2448) antibody used in Western Blot (WB). GTX132803
    • GTX132803 WB Image
      Untreated (–) and treated (+) NIH-3T3 whole cell extracts (30 µg) were separated by 5% SDS-PAGE, and the membrane was blotted with mTOR (phospho Ser2448) antibody (GTX132803) diluted at 1:1000. The signal was developed with Trident ECL plus-Enhanced.
      Top
  • Anti-mTOR (phospho Ser2448) antibody used in Western Blot (WB). GTX132803
    • GTX132803 WB Image
      Untreated (–) and treated (+) 293T whole cell extracts (60 µg) were separated by 5% SDS-PAGE, and the membrane was blotted with mTOR (phospho Ser2448) antibody (GTX132803) diluted at 1:1000.
      Top
  • Anti-mTOR (phospho Ser2448) antibody used in IHC (Formalin-fixed paraffin-embedded sections). GTX132803
    • GTX132803 IHC-P Image
      mTOR (phospho Ser2448) antibody detects mTOR (phospho Ser2448) protein at cytoplasm by immunohistochemical analysis in the presence of control peptide (left) or antigen-specific peptide (right).
      Sample: Paraffin-embedded human lung cancer.
      mTOR (phospho Ser2448) stained by mTOR (phospho Ser2448) antibody (GTX132803) diluted at 1:500.
      Top
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  • Reference for mTOR (phospho Ser2448) antibody
Application References Application Reactivity
Chen PH et al. The Inhibition of microRNA-128 on IGF-1-Activating mTOR Signaling Involves in Temozolomide-Induced Glioma Cell Apoptotic Death. PLoS One 11 (11):e0167096 (2016). WB Human
Target Bioinfo/ Predicted Isoform Cross Reactivity
SpeciesGene nameGene IDSwissProtOMIMIsoform (mRNA)Protein Accession#MW
Homo sapiensMTOR2475P42345601231NP_004949288.95

Cross-react Bioinfo
SpeciesGene nameGene IDSwissProtIsoform (mRNA)Protein Accession#MW
Mus musculusMtor56717Q9JLN9NM_020009NP_064393288.84
Rattus norvegicusMtor56718P42346NM_019906NP_063971288.85
    *MSDS
    MSDS-Glycerol.pdf
    MSDS-PBS.pdf
    MSDS-ProClin.pdf
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