Mre11 antibody [12D7] | GeneTex Inc.

5/24/2013 11:18:33 PM

	Tested applications		ELISA, ICC/IF, IHC-P, IP, WB
	Species Reactivity		Human
	Host Species / Clonality		Mouse Monoclonal
	Clone Name		12D7

Cat No: GTX70212

Package		Price	Qty
	100μg	USD 289.00

Availability



	Datasheet \| Reference \| Related Product \|

Datasheet for Mre11 antibody [12D7] (GTX70212)

Catalog Number	GTX70212
Product Name	Mre11 antibody [12D7]
Full Name	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
Synonyms	\| MRE11 \| MRE11B \| P49959 \| 600814 \| ATLD \| 4361 \| MRE11A \| HNGS1 \|
Product Description	Mouse monoclonal [12D7] to MRE11
Background	Mre11 is an 80 kDa protein that acts as a Mn+2 dependent double stranded DNA 3' to 5' exonuclease and a single stranded DNA endonuclease. It is part of a larger complex with Rad50, p95 (Nibrin) and possibly other associated proteins involved in the nucleolytic end-processing of double strand breaks and telomere maintenance.
Host	Mouse
Clonality	Monoclonal
Clone No	12D7
Subclass	IgG1
Immunogen	Amino acids 182-582 of Mre11 expressed in E. coli.
Antigen Species	Human
Species Reactivity	Human
Applications	ELISA, ICC/IF, IHC (Formalin-fixed paraffin-embedded sections), Immunoprecipitation, Western blot. The usefulness of this product in other applications has not been determined.
Application Note	For IF: Use at a dilution of 1:100 - 1:200. For IHC-P: Use at a dilution of 1:200. Incubation with the primary antibody was preceded by microwave treatment of the tissue section for antigen retrieval. For IP: Use at a dilution of 1:100. For WB: Use at a dilution of 1:1,000-1:2,000. Predicted molecular weight: 79 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher.
Positive Controls	T24
Target	Mre11
Predicted Target Size(KDa)	80 (Note)
Cellular Localization	Nuclear
Form Supplied	Liquid
Concentration	1 mg/ml
Purification	Protein G Affinity Purified
Purification Note	From ascitic fluid
Storage Buffer	Phosphate-buffered saline, pH 7.4, containing no preservatives
Storage Instruction	Keep as concentrated solution. Store at 4°C short term. For extended storage aliquot and store at -20°C or below. Avoid freeze-thaw cycles.

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Reference for Mre11 antibody [12D7] (GTX70212)

Application References	Application	Reactivity
Stewart, R. et al. (2013) Hum Mol Genet. 22:2495509.	Functional Assay
Simões, M. et al. (2013) Vet Microbiol. pii: S0378-1135(13)00056-4.	WB
Lee, J.H. et al. (2013) J Biol Chem. 288(18):12840-51.	Functional Assay
Tomimatsu, N.et al. (2012) DNA Repair (Amst). 11(4):441-8.
Sohn, S.Y. et al. (2012) J Virol. 86:9656-65.
Andrin, C. et al. (2012) Nucleus. 3(4):384-95.
Harding, S.M. et al. (2012) Cell Cycle. 11(7):1432-44.
Anderson, V.E. et al. (2011) Cancer Res. 71:463-72.	WB	Hu
Yanagihara, H. et al. (2011) Mol Cell. 43(5):788-97.	WB	Hu
Della-Maria, J.et al. (2011) J Biol Chem. 286:33845-53.
Gatei, M.et al. (2011) J Biol Chem. 286:31542-56.
Kozlov, S.V.et al. (2011) J Biol Chem. 286:9107-19.
Baydoun, H.H.et al. (2011) Blood 117:5897-906.	ICC/IF,WB	Hu
Karen, K.A. et al. (2011) J Virol. 85:4135-42.	ICC/IF,WB	Hu
Matsumoto, Y.et al. (2011) DNA Repair 10(3):314-21.	WB	Hu
Luo, Y. et al. (2011) J Virol. 85:133-145.	ICC/IF,WB	Hu
Orazio, N.I.et al. (2011) J Virol. 85:1887-92.	WB	Hu
Forrester, N.A.et al. (2011) J Virol. 85:2201-11.	ICC/IF,WB	Hu
Masuda, Y. et al. (2011) BBRC. 415(2):305-12.	WB	Hu
Offer, S.M. et al. (2010) PLoS One. 5(8):e12260.	WB	Hu
Guo, Z. et al. (2010) Cell Cycle. 9(24):4805-11.	WB
Adeyemi, R.O.et al. (2010) PLoS Pathog. 6(10):e1001141.	WB	Hu
Cha, H.et al. (2010) Cancer Res. 70:4112-22.
Chailleux, C. et al. (2010) Biochem J. 426:365-71.	WB	Hu
Balasubramanian, N.et al. (2010) J Virol. 84:12504-14.	WB
Schwartz, R.A. et al. (2009) J Virol. 83:6269-78.	WB	Hu
Waltes, R.et al. (2009) Am J Hum Genet 84:605-16.	ICC/IF,WB	Hu
Karen, K.A.et al. (2009) J Virol. 83(9):4565-73.	WB	Hu
Lins, S.et al. (2009) Gene. 447(1):12-7.	WB	Hu
Carlessi, L. et al. (2009) Cell Death Differ. 16:795-806.	WB	Hu
Carson, C.T.et al. (2009) EMBO J. 28:652-662.	ICC/IF,WB	Hu
Collaco, R.F. et al. (2009) Virology. 392(1):24-33.	ICC/IF,WB	Hu
Turaga, R.V. et al. (2009) Cell Cycle. 8(13):2080-92.	WB	Hu
Moschos, S.J. et al. (2009) Cancer Biol Ther. 8(19):1815-25.
Dellaire, G. et al. (2009) Cell Cycle. 8(22):3750-69.	WB	Hu
Roques, C. et al. (2009) EMBO J. 28(16):2400-13.	WB	Hu
Zou, Y. et al. (2009) Mol Cell Biol. 29:2390-7.	ICC/IF
Vago, R. et al. (2009) Cell Cycle. 8(16):2600-7.	WB	Hu
Crosby, M.E. et al. (2009) Cancer Res. 69:1221-9.	WB	Hu
Déry, U.et al. (2008) Mol Cell Biol. 28(9):3058-69.
Palii, S.S.et al. (2008) Mol Cell Biol. 28:752-71.	WB	Hu
Gregory, D.A et al. (2008) Virology. 373:124-36.	ICC/IF,WB	Hu
Cervelli, T.et al. (2008) J Cell Sci. 121:349-57.	ICC/IF	Hu
Haince, J.F. et al. (2008) J Biol Chem. 283:1197-208.
Lakdawala, S.S.et al. (2008) J Virol. 82:8362-72.	ICC/IF,WB	Hu
Schwartz, R.A. et al. (2007) J Virol. 81:12936-45.	ICC/IF,WB	Hu
Woo, J.L. et al. (2007) J Virol. 81:575-87.	WB	Hu
Kruger, L. et al. (2007) Carcinogenesis. 28:107-11.	WB	Hu
Xu, M.et al. (2007) Int J Hyperthermia. 23(4):343-51.
Cho, Y.W. et al. (2007) J Biol Chem. 282:20395-406.	WB	Hu
Bentle, M.S.et al. (2007) Cancer Res. 67:6936-45.	ICC/IF	Hu
Murakawa, Y. et al. (2007) Cancer Res. 67:8536-43.	ICC/IF	Hu
Barcaroli, D.et al. (2006) PNAS. 103:14808-12.	ICC/IF	Hu
Chai, W. et al. (2006) EMBO Rep. 7(2):225-30.	WB	Hu
Lovejoy, C.A. et al. (2006) Mol Cell Biol. 26:7977-90.	ICC/IF	Hu
Bekker-Jensen, S.et al. (2006) J Cell Biol. 173:195-206.	ICC/IF	Hu
Nakanishi, K. et al. (2006) Arch Pathol Lab Med. 130(9):1330-4.	IHC-P	Hu
Takemura, H.et al. (2006) J Biol Chem. 281:30814-23.	WB	Hu
Gueven, N. et al. (2006) Cancer Res. 66:907-12.	WB	Hu
Kozlov, S.V.et al. (2006) EMBO J. 25:3504-3514.	WB	Hu
Barcaroli, D.et al. (2006) PNAS. 103:14802-7.	ICC/IF	Hu
Varon, R. et al. (2006) Hum Mol Genet. 15:679-89.	WB	Hu
Dote, H.et al. (2006) Cancer Res. 66:9211-20.	ICC/IF,WB	Hu
van Veelen, L.R.et al. (2005) Mutat Res. 574(1-2):22-33.	ICC/IF
Al Rashid, S.T.et al. (2005) Cancer Res. 65:10810-21.	ICC/IF	Hu
Lilley, C.E.et al. (2005) PNAS. 102:5844-9.	ICC/IF,WB	Hu
Kim, J.S.et al. (2005) J Cell Biol. 170:341-47.	ICC/IF	Hu
Vo, A.T. et al. (2005) EMBO Rep. 6:438-44.	WB	Hu
Hart, L.S. et al. (2005) J Biol Chem. 280:1474-81.	WB	Hu
Wilkinson, D.E. et al. (2004) J Virol. 78:4783-96.	WB
Pichierri, P.et al. (2004) EMBO J. 23:3154-63.	ICC/IF,WB	Hu
Hořejší, Z. et al. (2004) Oncogene. 23:3122-7.	ICC/IF
Giannini, G. et al. (2004) Oncogene. 23:2640-7.	ICC/IF,WB	Hu
Dörk, T.et al. (2004) Am J Med Genet A. 126A(3):272-7.	WB
Zhang, X. et al. (2004) Mol Cell Biol. 24:9207-20.	WB	Hu
Robison, J.G.et al. (2004) J Biol Chem. 279:34802-10.	ICC/IF,WB	Hu
Fan, R.et al. (2004) Cancer Res. 64:8526-33.	WB	Hu
Xu, X. et al. (2003) FASEB J. 17:1842-8.	ICC/IF,WB	Hu
Celeste, A. et al. (2003) Nat Cell Biol. 5:675-9.
Uziel, T. et al. (2003) EMBO J. 22:5612-21.	ICC/IF,WB	Hu
Lukas, C. et al. (2003) Nat Cell Biol. 5:255-60.
Carson, C.T.et al. (2003) EMBO J. 22:6610-6620.	WB	Hu
Stewart, G.S. et al. (2003) Nature. 421:961-6.
Lee, J.H. et al. (2003) Mol Cancer Res. 1:674-81.	ICC/IF	Hu
Xu, X. et al. (2003) J Biol Chem. 278:8795-803.	ICC/IF	Hu
Stracker, T.H. et al. (2002) Nature. 418:348-52.	ICC/IF,WB	Hu
Kim, J.S.et al. (2002) J Biol Chem. 277:45149-53.	ICC/IF,WB	Hu
Limoli, C.L. et al. (2002) PNAS 99:233-8.	ICC/IF	Hu
Nakanishi, K. et al. (2002) Nat Cell Biol. 4:913-20.
Richie, C.T.et al. (2002) Mol Cell Biol. 22:8635-47.	ICC/IF	Hu
Pichierri, P.et al. (2002) Hum Mol Genet. 11:2531-46.	WB
Lombard, D.B. et al. (2000) Cancer Res. 60:2331-4.	ICC/IF	Hu
Harfst, E.et al. (2000) Mol Immunol. 37(15):915-29.	WB
Wang, Y. et al. (2000) Genes & Dev. 14:927-39.	ICC/IF,IP	Hu
Gatei, M. et al. (2000) Nat Genet. 25:115-9.

Clone References	Application	Reactivity
Zheng, L. et al. (2009) Nucleic Acids Res. 37:2645-57.	WB	Hu

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