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p107 antibody


  • Host / ClonalityRabbit Polyclonal
  • ApplicationsIHC-Fr, IP, WB
  • Species reactivityHuman, Mouse, Rat
Cat No: GTX22451
Package Price Qty
1 mlUSD 319.00
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  • Datasheet
  • Application Information: p107 antibody

Catalog Number GTX22451
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Product Name p107 antibody
See all p107 products
ApplicationsIHC-Fr, IP, WB
Application NoteFor Western Blotting, use at a dilution of 1:200 Optimal dilutions should be determined by the user.
Positive ControlsSK-BR-3 and NIH / 3T3 lysate.
Concentration0.2 mg/ml (Please refer to the vial label for the specific concentration)

  • Specifications: p107 antibody

Full Nameadenylate cyclase 1 (brain)
BackgroundThe pocket protein family consists of three structurally and functionally related proteins, Rb (retinoblastoma), p107, and p130. This family of tumor suppressors function to regulate important cellular transcription factors, such as the E2F family. The E2F proteins regulate the expression of genes whose products are important for cell cycle progression. The inactivation Rb is catalyzed by CDK phosphorylation thereby releasing E2F during the G1-S phase cellular progression. Unchecked inactivation of Rb in G1 phase has been indicated as a universal mechanism underlying cellular transformation . While Rb has been the most studied among the pocket proteins, p107 and p130 have also been shown to be key regulators of E2F. Several studies have also provided evidence that p107/p130 provide different functions in E2F regulation than does Rb. Rb, p107, and p130 each contain a conserved 'A/B pocket', which is the target of several viral oncoproteins, namely SV40 large T-antigen and adenovirus E1A.
Synonyms107 retinoblastoma -associated protein CP107 MGC40006 p107 P107 PRB1 retinoblastoma-like 1 (p107)
HostRabbit
ClonalityPolyclonal
IsotypeIgG
ImmunogenSynthetic peptide (Human) (C terminal).
Antigen SpeciesHuman
Species ReactivityHuman, Mouse, Rat
ConjugationUnconjugated

  • Storage Conditions: p107 antibody

Storage BufferPreservative: 0.1% Sodium Azide; Constituents: 0.2% Gelatin, PBS
Storage InstructionStore this product at 4 °C, do not freeze. The product is stable for one year from the date of shipment.
NotesFor In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
ResearchArea
  • Neuroscience > Circadian rhythm
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p107 antibody validated data
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All products are for research use only—Not for use in diagnostic procedures.