|Full Name||cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)|
|Product Description||Rabbit Polyclonal antibody to p18 INK4c (cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4))|
|Background||The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq]|
|Synonyms||p18 Antibody , p18-INK4C Antibody , cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) Antibody , CDKN2C Antibody , INK4C Antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human p18 INK4c. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Rat, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Human (100%), Rat (88%), Rhesus Monkey (100%), Bovine (89%)|