|Full Name||cyclin-dependent kinase inhibitor 1A (p21, Cip1)|
|Product Description||Rabbit Polyclonal antibody to p21 Cip1 (cyclin-dependent kinase inhibitor 1)|
|Background||This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported. [provided by RefSeq]|
|Synonyms||wild-type p53-activated fragment 1 antibody, p21CIP1 antibody, melanoma differentiation associated protein 6 antibody, cyclin-dependent kinase inhibitor 1A (p21, Cip1) antibody, cyclin-dependent kinase inhibitor 1 antibody, WAF1 antibody, SDI1 antibody, P21 antibody, MDA-6 antibody, DNA synthesis inhibitor antibody, CIP1 antibody, CDKN1A antibody, CDKN1 antibody, CDK-interaction protein 1 antibody, CDK-interacting protein 1 antibody, CAP20 antibody|
|Cellular Localization||Cytoplasm , Nucleus|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human p21 Cip1. The exact sequence is proprietary.|
|Species Reactivity||Human, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Cat, Sheep, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Cat (83%), Sheep (80%), Rhesus Monkey (97%), Bovine (81%)|