|Full Name||mitogen-activated protein kinase 14|
|Product Description||Rabbit Polyclonal antibody to p38 (mitogen-activated protein kinase 14)|
|Background||The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq]|
|Synonyms||CSBP antibody, CSBP1 antibody, CSBP2 antibody, CSPB1 antibody, EXIP antibody, Mxi2 antibody, PRKM14 antibody, PRKM15 antibody, RK antibody, SAPK2A antibody, p38 antibody, p38ALPHA antibody, MAPK14 antibody, mitogen-activated protein kinase 14 antibody, Csaids binding protein antibody, MAP kinase Mxi2 antibody, cytokine suppressive anti-inflammatory drug-binding protein antibody, mitogen-activated protein kinase p38 alpha antibody, p38 mitogen activated protein kinase antibody, MAX-interacting protein 2 antibody, CSAID-binding protein antibody, p38 MAP kinase antibody, cytokine suppressive anti-inflammatory drug binding protein antibody, stress-activated protein kinase 2A antibody, MAP kinase p38 alpha antibody, MAP kinase 14 antibody, p38alpha Exip antibody|
|Cellular Localization||Cytoplasm (By similarity) , Nucleus |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human p38 MAPK. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Xenopus laevis, Dog, Sheep, Chimpanzee, Bovine|
|Predict Reactivity Note||Rat (98%), Xenopus laevis (92%), Dog (100%), Sheep (100%), Chimpanzee (100%), Bovine (100%)|