|Full Name||tumor protein p53|
|Synonyms||tumor suppressor homolog p53 antibody, cellular tumor antigen p53 antibody, etID22686.5 antibody, tumor suppressor p53 antibody, brp53 antibody, drp53 antibody, fb40d06 antibody, p53 antibody, wu:fb40d06 antibody, zgc:111919 antibody, tp53 antibody, tumor protein p53 antibody|
|Product Description||Rabbit Polyclonal antibody to p53 (tumor protein p53)|
|Background||Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. |
|Immunogen||Recombinant fragment contain a sequence corresponding to a region within amino acids 1 and 164 of p53|
Not tested in other applications.
|IHC (Whole mount)||1:100-1:500*
*Optimal dilutions/concentrations should be determined by the researcher.
|Positive Controls||zebrafish (irradiation)|
|Predicted Target Size||42 kDa|
|Cellular Localization||Cytoplasm (By similarity) , Nucleus |
|Purification||Purified by antigen-affinity chromatography.|
|Storage Buffer||1XPBS, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Storage Instruction||Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.|
|Notes||For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption. |