| Catalog Number | GTX128135 |
| Product Name | p53 antibody |
| Full Name | tumor protein p53 |
| Synonyms | tumor suppressor homolog p53 antibody | cellular tumor antigen p53 antibody | etID22686.5 antibody | tumor suppressor p53 antibody | brp53 antibody | drp53 antibody | fb40d06 antibody | p53 antibody | wu:fb40d06 antibody | zgc:111919 antibody | tp53 antibody | tumor protein p53 antibody |
| Product Description | Rabbit Polyclonal antibody to p53 (tumor protein p53) |
| Background | Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. |
| Host | Rabbit |
| Clonality | Polyclonal |
| Subclass | IgG |
| Immunogen | Recombinant fragment contain a sequence corresponding to a region within amino acids 1 and 164 of p53 |
| Species Reactivity | zebrafish |
| Applications | Western blot, IHC (Whole mount). The usefulness of this product in other applications has not been determined. |
| Application Note | Suggested starting dilutions are as follows: WB: 1:500-1:3000, IHC (Whole mount): 1:100-1:500. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user. |
| Positive Controls | zebrafish (irradiation) |
| Target | p53 |
| Cellular Localization | Cytoplasm (By similarity) | Nucleus | |
| Form Supplied | Liquid |
| Concentration | 1 mg/ml |
| Purification | Purified by antigen-affinity chromatography. |
| Storage Buffer | 1XPBS, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
| Storage Instruction | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Notes | For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption. |