p70 S6K antibody
|Applications||ICC/IF, IHC-P, WB|
Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||59 kDa (note)
|Positive Controls||Neuro 2A , C8D30 , NIH-3T3 , Raw264.7 , C2C12 , PC-12 , Rat2|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||ribosomal protein S6 kinase, 70kDa, polypeptide 1|
|Product Description||Rabbit Polyclonal antibody to S6K (ribosomal protein S6 kinase, 70kDa, polypeptide 1)|
|Background||This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding this gene and overexpression of this kinase are seen in some breast cancer cell lines. Alternate translational start sites have been described and alternate transcriptional splice variants have been observed but have not been thoroughly characterized. [provided by RefSeq]|
|Synonyms||PS6K antibody, S6K antibody, S6K1 antibody, STK14A antibody, p70(S6K)-alpha antibody, p70-S6K antibody, p70-alpha antibody, RPS6KB1 antibody, ribosomal protein S6 kinase I antibody, p70 S6 kinase, alpha 1 antibody, serine/threonine kinase 14 alpha antibody, serine/threonine-protein kinase 14A antibody, p70 S6KA antibody, P70S6K1 antibody, 70 kDa ribosomal protein S6 kinase 1 antibody, p70 S6 kinase, alpha 2 antibody, ribosomal protein S6 kinase beta-1 antibody, p70 S6K-alpha antibody, S6K-beta-1 antibody, ribosomal protein S6 kinase, 70kDa, polypeptide 1 antibody|
|Cellular Localization||Cytoplasm (By similarity) , Cell junction , synapse , synaptosome |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human p70 S6K. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Xenopus laevis, Rabbit, Chicken, Bovine|
|Predict Reactivity Note||Xenopus laevis (87%), Rabbit (99%), Chicken (96%), Bovine (99%)|