|Product Description||Rabbit Polyclonal antibody to phospholamban (phospholamban)|
|Background||The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure. [provided by RefSeq]|
|Synonyms||CMD1P antibody, PLB antibody, PLN antibody, cardiac phospholamban antibody, phospholamban antibody|
|Cellular Localization||Mitochondrion membrane; Single-pass membrane protein , Sarcoplasmic reticulum |
|Immunogen||Full length human phospholamban Recombinant protein.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Dog, Pig, Rabbit, Chicken, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Rat (98%), Dog (96%), Pig (96%), Rabbit (98%), Chicken (82%), Rhesus Monkey (98%), Bovine (94%)|