|Full Name||pygopus 2|
|Product Description||Rabbit Polyclonal antibody to pygopus 2 (pygopus 2)|
|Background||ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Is required but not sufficient to confer resistance against the lethal effects of reactive nitrogen intermediates (RNI), antimicrobial molecules produced by activated macrophages and other cell types. |
|Synonyms||pygopus homolog 2 antibody, 1190004M21Rik antibody, mpygo2 antibody, Pygo2 antibody, pygopus 2 antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of mouse pygopus 2. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Pig, Bovine|
|Predict Reactivity Note||Rat (100%), Pig (98%), Bovine (98%)|