|Full Name||plasminogen activator, tissue|
|Product Description||Rabbit Polyclonal antibody to tPA (plasminogen activator, tissue)|
|Background||This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq]|
|Synonyms||DKFZp686I03148 antibody, T-PA antibody, TPA antibody, PLAT antibody, plasminogen activator, tissue type antibody, tissue plasminogen activator (t-PA) antibody, alteplase antibody, tissue-type plasminogen activator antibody, reteplase antibody, t-plasminogen activator antibody, plasminogen activator, tissue antibody|
|Cellular Localization||Secreted , extracellular space |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human tPA. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Pig (82%), Bovine (82%)|