|Full Name||plasminogen activator, urokinase receptor|
|Product Description||Rabbit Polyclonal antibody to uPAR (plasminogen activator, urokinase receptor)|
|Background||This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq]|
|Synonyms||CD87 antibody, U-PAR antibody, UPAR antibody, URKR antibody, PLAUR antibody, urokinase plasminogen activator surface receptor antibody, u-plasminogen activator receptor form 2 antibody, monocyte activation antigen Mo3 antibody, plasminogen activator, urokinase receptor antibody|
|Cellular Localization||Isoform 1: Cell membrane; Lipid-anchor , GPI-anchor , Isoform 2: Secreted |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human uPAR. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Chimpanzee (83%)|