|Full Name||solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6|
|Product Description||Rabbit polyclonal antibody to vGLUT2|
|Background||FUNCTION: Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. |
TISSUE SPECIFICITY: Expressed in brain. Expressed in hippocampal neurons (at protein level).
DEVELOPMENTAL STAGE: Expressed in brain throughout development. Transiently expressed in hippocampal neurons during the first week after birth, with expression decreasing thereafter.
MISCELLANEOUS: Mice lacking this protein exhibit an elevated rate of perinatal lethality. Surviving animals display a strong reduction in evoked glutamergic responses in thalamic neurons. Reduction of protein level in homozygous and heterozygous knockouts leads to a graded reduction in the amplitude of the postsynaptic response to single vesicle fusion in thalamic neurons, consistent with a role for this protein in determining quantal size.
|Synonyms||Vesicular glutamate transporter 2, VGlU2 140919, SLC17A6, Differentiationassociated Na(+)dependent in, Diffe, 84487, Solute carrier family17 member6, Differentiation-associated Na(+)-dependent in, Vesicular glutamate transporter2, Differentiationassociated BNPI, VGlU2140919, Solute carrier family 17 member 6, VGlU2|
|Cellular Localization||Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. |
Membrane; Multi-pass membrane protein.
Cell junction, synapse, synaptosome.
|Immunogen||A synthetic peptide from the n-terminal part of rat, mouse VGluT2 conjugated to an immunogenic carrier protein was used as the immunogen.|
|Species Reactivity||Mouse, Rat|