A Well-Cited Nrf2 Antibody for Cellular Redox Research

Reactive oxygen species (ROS) and reactive nitrogen species (RNS), though essential for many physiological pathways, inflict damage on the cell’s genome and its functional components. An imbalance between ROS/RNS levels and a cell’s antioxidant defenses leads to loss of redox equilibrium and potentially chronic pathologies. A major player in these defenses is Nrf2, a bZIP transcription factor (1). Under normal conditions, Nrf2 is retained largely in the cytosol through Keap1/Cul3/Rbx1- and GSK3β-mediated mechanisms. With oxidative stress, Nrf2 is freed to move to the nucleus where it binds antioxidant response elements (AREs) on DNA and recruits chromatin modifiers and transcriptional coactivators to drive expression of various antioxidant response and detoxification effectors. Thus, Nrf2 is of paramount importance for survival during oxidant challenge, and further research into its biology may reveal novel therapeutic approaches for a multitude of serious human diseases.

GeneTex is proud to offer an outstanding, well-cited NRF2 antibody validated for use in many species and for at least five applications (i.e., WB, IP, IHC, ICC/IF, and ChIP). GeneTex also provides an extensive selection of antibodies for mitochondria research. Please click here to view our complete listing.