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SARS-CoV-2 (COVID-19) Antibodies and Reagents

07-Sep-2021

SARS-CoV-2 (COVID-19) Antibodies and Reagents

 

GeneTex continues to expand and validate its comprehensive catalog of outstanding antibodies and reagents for SARS-CoV-2 (COVID-19) research. This includes ongoing assessment of our antibodies’ ability to detect important viral variants, particularly the WHO-designated Variants of Concern (VOCs). For more information, please see Tables 1-2 below.

In GeneTex’s SARS-CoV-2 spike antibody portfolio, the anti-spike RBD [HL1014] and anti-spike S1 [HL13402] recombinant rabbit clones exhibit high affinity for all SARS-CoV-2 spike proteins, including those of the B.1.1.7 (Alpha), B.1.351 (Beta), P.1 (Gamma), and B.1.617.2 (Delta) variants (Table 1). Clone [HL13402] also performs exceptionally well when paired with the widely published mouse clone [1A9] (against the S2 subunit) for sandwich ELISA.

GeneTex’s recombinant rabbit nucleocapsid antibodies display high affinity for the WIV04/2019 (reference sequence) human cell-expressed full-length SARS-CoV-2 nucleocapsid protein, with EC50 values ranging from 0.006-0.074 nM. Importantly, one matched nucleocapsid antibody pair (i.e., GTX635689 and GTX635686) demonstrates superior sensitivity in sandwich ELISA and lateral flow assays. This pair also recognizes the nucleocapsid protein of the B.1.617.2 (Delta) variant, as do several other individual recombinant clones (Table 2).

Taken together, GeneTex’s large selection of SARS-CoV-2 antibodies virtually guarantees that you will find a reagent appropriate for your desired application.

 

Table 1. SARS-CoV-2 Variant Detection by GeneTex Spike Antibody Clones

Targeted Region of Spike Antibody Cat. No. Clone WIV04/2019 (reference sequence) B.1.1.7 (Alpha) B.1.351 (Beta) P.1 (Gamma) B.1.617.2 (Delta)
RBD GTX635807 HL1014
RBD GTX635791 HL1002
RBD GTX635792 HL1003
RBD GTX635793 HL1004
S1 GTX635713 HL13402
S1 GTX635708 GT263 X X X Not Tested
S2 GTX632604 1A9
S2 GTX635693 HL237 X

Recombinant spike proteins (trimer) derived from different SARS-CoV-2 variants were assayed by indirect ELISA using the specified GeneTex monoclonal antibodies.

 

Table 2. SARS-CoV-2 Delta Variant Detection by GeneTex Nucleocapsid Antibody Clones

Targeted Protein Antibody Cat. No. Clone WIV04/2019 (reference sequence) B.1.617.2 (Delta)
Nucleocapsid GTX635686 HL448
Nucleocapsid GTX635689 HL5511
Nucleocapsid GTX635685 HL5410
Nucleocapsid GTX635688 HL455
Nucleocapsid GTX635679 HL344

Recombinant nucleocapsid proteins derived from different SARS-CoV-2 variants were assayed by ELISA (either indirect or sandwich ELISA) using the specified GeneTex monoclonal antibodies.

  Strong detection. Defined as OD450 value >1 when 1μg/ml protein was used.
  Weak detection. Defined as OD450 value >1 when 4μg/ml protein was used.
X   No detection. Defined as OD450 value <1 when 4μg/ml protein was used.

 

 

Full Listing of Products for SARS-CoV-2 (COVID-19) Research

Anti-Spike Antibodies | Anti-Nucleocapsid Antibodies | Other Antibodies | ELISA Pairs | ELISA Kit | Lateral Flow Recommended Pairs | Recombinant Proteins | Cell Pellet Blocks / Slides | Overexpression Lysates | Products for Host Cell Entry Research | Featured Antibodies | Highlighted ELISA Pairs | Highlighted Proteins

 

Anti-Spike Antibodies

Recombinant Citation-Support Protein Overexpression 

  Product Name Clonality EC50 Applications Cat. No.
Spike S1 antibody [HL1] Rb recAb 117 pM WB, ICC/IF, ELISA, Sandwich ELISA GTX635656
  Spike S1 antibody [HL6] Rb recAb 251 pM WB, ICC/IF, IHC-P, FACS, ELISA, Sandwich ELISA, IHC-P (cell pellet) GTX635654
Spike S1 antibody [HL134] Rb recAb 552 pM WB, ICC/IF, ELISA, IHC-P (cell pellet) GTX635671
Spike S1 antibody [HL263] Rb recAb 365 pM WB, ICC/IF, ELISA, Sandwich ELISA, IHC-P (cell pellet) GTX635672
Spike S1 antibody [HL13402] Rb recAb   WB, ICC/IF, ELISA, Sandwich ELISA GTX635713
  Spike S1 antibody [GT263] Ms mAb   WB, ICC/IF, ELISA, Sandwich ELISA, IHC-P (cell pellet) GTX635708
  Spike S1 antibody Rb pAb   WB, ICC/IF, ELISA GTX135384
Spike RBD antibody [HL1002] Rb recAb   ELISA, Neutralizing/Inhibition, Sandwich ELISA GTX635791
Spike RBD antibody [HL1003] Rb recAb 7.49 pM ICC/IF, ELISA, Neutralizing/Inhibition, Sandwich ELISA GTX635792
Spike RBD antibody [HL1003-HU] Hu recAb   ELISA, Neutralizing/Inhibition, Sandwich ELISA GTX635866
Spike RBD antibody [HL1004] Rb recAb 25.13 pM ICC/IF, ELISA, Neutralizing/Inhibition, Sandwich ELISA GTX635793
Spike RBD antibody [HL1004] (HRP) Rb recAb   ELISA, Sandwich ELISA GTX635793-01
Spike RBD antibody [HL1014] Rb recAb 28.77 pM ICC/IF, ELISA, Sandwich ELISA GTX635807
Spike RBD antibody [HL257] Rb recAb   WB, ICC/IF, IHC-P, ELISA, IHC-P (cell pellet) GTX635692
SARS-CoV-2 (COVID-19) Spike RBD antibody [HL1003] (HRP) Rb recAb   ELISA, Sandwich ELISA GTX635792-01
  Spike RBD antibody [GT5449] Ms mAb   WB, ELISA, Sandwich ELISA GTX636042
  Spike RBD antibody Rb pAb   WB, ICC/IF, FACS, ELISA, Neutralizing/Inhibition, Sandwich ELISA, IHC-P (cell pellet) GTX135709
  Spike RBD antibody Rb pAb   WB, ICC/IF GTX135385
Spike S2 antibody [HL237] Rb recAb   WB, ICC/IF, ELISA, Sandwich ELISA, IHC-P (cell pellet) GTX635693
Spike S2 antibody [HL1038] Rb recAb   WB, ICC/IF, ELISA, Sandwich ELISA, IHC-P (cell pellet) GTX635910
  Spike S2 antibody [GT745] Ms mAb   WB, ELISA, Sandwich ELISA, IHC-P (cell pellet) GTX636037
  Spike S2 antibody [GT8110] Ms mAb   WB, ELISA, Sandwich ELISA, IHC-P (cell pellet) GTX636038
Spike S2 / S2' antibody [HL1039] Rb recAb   WB, ICC/IF, ELISA, Sandwich ELISA, IHC-P (cell pellet) GTX635911
  Spike S2 / S2' antibody Rb pAb   WB, ICC/IF, ELISA, Sandwich ELISA GTX135386
Spike antibody [1A9] Ms mAb   WB, ICC/IF, IHC-P, FACS, IP, ELISA, EM, Sandwich ELISA, IHC-P (cell pellet) GTX632604
Spike antibody Rb pAb   WB, ICC/IF, IHC-P, ELISA, Sandwich ELISA, IHC-P (cell pellet) GTX135356
Spike antibody Rb pAb   WB, ICC/IF, ELISA, Sandwich ELISA GTX135360
Spike antibody [CR3022] Hu recAb   ELISA, Neutralizing/Inhibition GTX01555
Spike antibody [CR3022-RB] Rb recAb   ELISA, Neutralizing/Inhibition GTX01556
  Spike (N439K Mutant) antibody Rb pAb   WB GTX135961
  Spike (A222V Mutant) antibody Rb pAb   WB GTX135960

 

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Anti-Nucleocapsid Antibodies

Recombinant Citation-Support Protein Overexpression 

  Product Name Clonality EC50 Applications Cat. No.
  Nucleocapsid antibody [HL455-MS] Ms mAb   WB, ICC/IF, ELISA, Sandwich ELISA, IHC-P (cell pellet) GTX635712
Nucleocapsid antibody [HL5410] Rb recAb 9 pM WB, ICC/IF, ELISA, Lateral Flow, Sandwich ELISA, IHC-P (cell pellet) GTX635685
Nucleocapsid antibody [HL5410] (Gold) Rb recAb   Immunoassay GTX635685-17
  Nucleocapsid antibody [HL5511] Rb recAb 14 pM WB, ICC/IF, ELISA, Lateral Flow, Sandwich ELISA, IHC-P (cell pellet) GTX635689
Nucleocapsid antibody [HL146] Rb recAb 50 pM WB, ICC/IF, ELISA, Sandwich ELISA GTX635680
Nucleocapsid antibody [HL249] Rb recAb 16 pM WB, ICC/IF, ELISA, Sandwich ELISA, IHC-P (cell pellet) GTX635678
Nucleocapsid antibody [HL344] Rb recAb 74 pM WB, ICC/IF, IHC-P, IHC-Fr, ELISA, Sandwich ELISA, IHC-P (cell pellet) GTX635679
Nucleocapsid antibody [HL448] Rb recAb 11 pM WB, ICC/IF, IHC-P, ELISA, Lateral Flow, Sandwich ELISA, IHC-P (cell pellet) GTX635686
Nucleocapsid antibody [HL448] (HRP) Rb recAb   WB, ELISA, Sandwich ELISA GTX635686-01
Nucleocapsid antibody [HL453] Rb recAb 6 pM WB, ICC/IF, ELISA, IHC-P (cell pellet) GTX635687
Nucleocapsid antibody [HL455] Rb recAb 6 pM WB, ICC/IF, ELISA, Lateral Flow, Sandwich ELISA, IHC-P (cell pellet) GTX635688
  Nucleocapsid antibody [GT113] Ms mAb   WB, ICC/IF, ELISA, Sandwich ELISA GTX635808
  Nucleocapsid antibody [6H3] Ms mAb   WB, ICC/IF, IHC-P, IP, ELISA, Sandwich ELISA, IHC-P (cell pellet) GTX632269
  Nucleocapsid antibody Rb pAb   WB, ICC/IF, IHC-P, FACS, IP, ELISA, Sandwich ELISA, IHC-P (cell pellet) GTX135357
Nucleocapsid antibody Rb pAb   WB, IHC-P, ELISA, Sandwich ELISA, IHC-P (cell pellet) GTX135361
  Nucleocapsid antibody Rb pAb   WB, IHC-P (cell pellet) GTX135570

 

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Other SARS-CoV-2 Antibodies

Citation-Support  

  Product Name Clonality Applications Cat. No.
  Envelop antibody Rb pAb WB GTX136046
  RdRp (nsp12) antibody Rb pAb WB, ICC/IF GTX135467
  RdRp (nsp12) antibody Rb pAb WB GTX135469
  3CLpro (nsp5) antibody Rb pAb WB GTX135470
  3CLpro (nsp5) antibody Rb pAb WB GTX135648
  ORF8 antibody Rb pAb WB, ICC/IF, IHC-P (cell pellet) GTX135591
  nsp1 antibody Rb pAb WB, ICC/IF GTX135586
  nsp1 antibody Rb pAb WB, ICC/IF, IHC-P (cell pellet) GTX135612
  nsp2 antibody Rb pAb WB, ICC/IF GTX135717
  nsp3 / PL-pro antibody Rb pAb WB GTX135796
nsp3 antibody Rb pAb WB, ICC/IF, IHC-P (cell pellet) GTX135589
nsp3 antibody Rb pAb WB, ICC/IF GTX135614
  nsp7 antibody Rb pAb WB GTX135728
ORF7a antibody [3C9] Ms mAb WB, ICC/IF GTX632602
nsp8 antibody [5A10] Ms mAb WB, ICC/IF, FACS GTX632696
  nsp8 antibody Rb pAb WB, IHC-P (cell pellet) GTX135729
  nsp8 antibody Rb pAb WB, ICC/IF, IHC-P (cell pellet) GTX135730
  nsp9 antibody Rb pAb WB, ICC/IF GTX135731
  nsp9 antibody Rb pAb WB, ICC/IF, IHC-P (cell pellet) GTX135732
  nsp10 antibody Rb pAb WB, ICC/IF, IHC-P (cell pellet) GTX135733
  nsp10 antibody Rb pAb WB, ICC/IF GTX135734
  nsp15 antibody Rb pAb WB, ICC/IF GTX135737
  nsp15 antibody Rb pAb WB, ICC/IF GTX135738
  nsp11 antibody Rb pAb WB, ICC/IF GTX135742

 

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ELISA Antibody Pairs

  Product Name Sensitivity Cat. No.
  Spike RBD ELISA Pair [HL1014 / HL1003]   GTX500046
  Spike RBD ELISA pair [HL1014/HL1004]   GTX500047
  Spike ELISA Pair [1A9 / HL263]   GTX500041
  Spike ELISA Pair [1A9 / HL13402]   GTX500043
  Spike ELISA pair [1A9 / HL1003]   GTX500048
  Nucleocapsid ELISA Pair [HL5511 / HL448] 39.06 pg/mL GTX500045
Nucleocapsid ELISA Pair [HL5410 / HL455-MS] 2.68 pg/mL GTX500042

 

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SARS-CoV-2 ELISA Kit

  Product Name Sensitivity Applications Cat. No.
SARS-CoV-2 (COVID-19) Spike-ACE2 Binding / Neutralization Assay Kit N/A Neutralizing/Inhibition GTX536401
  Nucleocapsid Protein Sandwich ELISA Kit 18 pg/ml ELISA, Sandwich ELISA GTX535824
  SARS-CoV-2 (COVID-19) Spike RBD Protein Sandwich ELISA Kit 1.8 pg/ml ELISA, Sandwich ELISA GTX536267

 

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Lateral Flow Assay (Recommended Antibody Pairs)

Recombinant  Citation-Support

Antibody Pair   Product Name Clonality EC50 Cat. No.
Pair I   Nucleocapsid antibody [HL5511] Rb recAb 14 pM GTX635689
Nucleocapsid antibody [HL448] Rb recAb 11 pM GTX635686
Pair II Nucleocapsid antibody [HL5410] Rb recAb 9 pM GTX635685
Nucleocapsid antibody [HL455] Rb recAb 6 pM GTX635688

 

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Recombinant Proteins

Citation-Support

  Product Name Expression System Applications Cat. No.
Spike (ECD) protein, His tag (active) HEK293 ELISA, Sandwich ELISA, Functional Assay GTX135972-pro
  Spike (D614G Mutant) protein (ECD), His tag (active) HEK293 ELISA, Functional Assay GTX02575-pro
  Spike (ECD) Protein, B.1.1.7 / Alpha variant, His tag (active) HEK293 Functional Assay GTX136059-pro
  Spike (ECD) Protein, B.1.351 / Beta variant, His tag (active) HEK293 ELISA, Functional Assay GTX136061-pro
  Spike (ECD) Protein, P.1 / Gamma variant, His tag (active) HEK293 ELISA, Functional Assay GTX136091-pro
  Spike (ECD) Protein, B.1.617.2 / Delta variant, His tag (active) HEK293 ELISA, Sandwich ELISA, Functional Assay GTX136432-pro
  Spike S1 Protein, B.1.1.7 / Alpha variant, His tag (active) HEK293 Functional Assay GTX136085-pro
  Spike S1 Protein, P.1 / Gamma variant, His tag (active) HEK293 Functional Assay

GTX136094-pro

  Spike S1 Protein, B.1.351 / Beta variant, His tag (active) HEK293 Functional Assay

GTX136095-pro

  Spike S1 protein, His and Avi tag (active) HEK293 ELISA, Functional Assay GTX01548-pro
  Spike S1 protein, His tag (active) HEK293 ELISA, Sandwich ELISA, Functional Assay GTX135817-pro
  Spike S2 (ECD) protein, mouse IgG Fc tag HEK293 ELISA, Sandwich ELISA GTX135684-pro
  Spike S2 (ECD) protein, human IgG Fc tag HEK293 ELISA, Sandwich ELISA GTX01559-pro
  Spike S2 Protein, B.1.1.7 / Alpha variant, His tag HEK293 ELISA, Sandwich ELISA GTX136023-pro
  Spike RBD Protein, B.1.1.7 with E484K, His tag (active) HEK293 Functional Assay GTX136058-pro
  Spike RBD Protein, B.1.1.7 / Alpha variant, His tag (active) HEK293 ELISA, Sandwich ELISA, Functional Assay

GTX136014-pro

  Spike RBD Protein, B.1.1.7 / Alpha variant, mouse Fc tag (active) HEK293 ELISA, Functional Assay GTX136024-pro
  Spike RBD Protein, B.1.351 / Beta variant, His tag (active) HEK293 ELISA, Sandwich ELISA, Functional Assay

GTX136022-pro

  Spike RBD Protein, P.1 / Gamma variant, His tag (active) HEK293 Functional Assay GTX136043-pro
  Spike RBD Protein, B.1.617.2 / Delta variant, His tag (active) HEK293 ELISA, Functional Assay GTX136332-pro
  Spike RBD Protein, AY.1 / Delta plus variant, His tag HEK293 Functional Assay GTX136333-pro
  Spike RBD Protein, B.1.617.1 / Kappa variant, His tag (active) HEK293 ELISA, Functional Assay GTX136058-pro
  Spike RBD protein, His tag (active) HEK293 ELISA, Sandwich ELISA, Functional Assay GTX136090-pro
  Nucleocapsid protein, His tag E. coli ELISA, Sandwich ELISA GTX135357-pro
Nucleocapsid protein, His tag HEK293 ELISA, Sandwich ELISA GTX135592-pro
  Nucleocapsid protein,His tag (Gold) HEK293 Immunoassay GTX135746-pro
  Envelope protein, His and Avi tag E. coli   GTX01547-pro
  Envelope Protein, GST and His Tag HEK293   GTX01565-pro
  3CLpro (nsp5) protein, His tag E. coli   GTX135648-pro
  3CLpro (nsp5) protein, His and Avi tag E. coli   GTX01557-pro

 

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Cell Pellet Blocks / Slides

Citation-Support

  Product Name Applications Cat. No.
Spike FFPE 293T cell pellet block IHC-P, IHC-P (cell pellet) GTX435640
  Spike S1 FFPE 293T cell pellet block IHC-P (cell pellet) GTX435643
  Spike S2 FFPE 293T cell pellet block IHC-P (cell pellet) GTX435644
Nucleocapsid FFPE 293T cell pellet block IHC-P, IHC-P (cell pellet) GTX435641
  Envelope FFPE 293T cell pellet block IHC-P (cell pellet) GTX435642
  Membrane FFPE 293T cell pellet block IHC-P (cell pellet) GTX435645
  Spike FFPE 293T cell pellet slide IHC-P (cell pellet) GTX435744

 

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Overexpression Lysates

Product Name Applications Cat. No.
Spike overexpression 293T whole cell lysate WB, ELISA GTX535664
Spike S1 overexpression 293T whole cell lysate WB GTX535663
Nucleocapsid overexpression 293T whole cell lysate WB, ELISA GTX535665

 

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Products for Host Cell Entry Research

Recombinant Citation-Support KOKD-Validation  Protein Overexpression

  Product Name Clonality or Expression System Applications Cat. No.
  ACE2 antibody [GT19410] Ms mAb WB, IHC-P, ELISA, Sandwich ELISA

GTX635897

   ACE2 antibody [N1N2], N-term Rb pAb WB, ICC/IF, IHC-P, FACS, ELISA GTX101395
   ACE2 antibody [SN0754] Rb recAb WB, ICC/IF, IHC-P GTX01160
  ACE2 antibody Rb pAb WB, ICC/IF, IHC-P, ELISA GTX15349
  Human ACE2(ECD) protein, mouse IgG Fc tag HEK 293 ELISA, Functional Assay GTX135683-pro
  Human ACE2 protein, His and Avi tag HEK 293 ELISA, Functional Assay GTX01550-pro
  TMPRSS2 antibody [N2C3] Rb pAb WB, IHC-P GTX100743
  Camostat mesylate   TMPRSS2 inhibitor GTX01523

 

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Featured Antibodies

Recombinant Citation-Support Protein Overexpression

 

SARS-CoV / SARS-CoV-2 (COVID-19) spike antibody [1A9] (GTX632604)

SARS-CoV / SARS-CoV-2 (COVID-19) spike antibody [1A9] 
(GTX632604)

Protein Overexpression
SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL344]

SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL344]
 (GTX635679)

SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL344]

SARS-CoV-2 (COVID-19) Spike RBD antibody [HL1003] (GTX635792)

SARS-CoV-2 (COVID-19) Spike S1 antibody [HL13402]

SARS-CoV-2 (COVID-19) Spike S1 antibody [HL13402] (GTX635713)

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ELISA Kits and Pairs 

Nucleocapsid Protein Sandwich ELISA Kit

Nucleocapsid Protein Sandwich ELISA Kit 
(GTX535824)

Spike RBD ELISA pair [HL1014/HL1004]

Spike RBD ELISA pair [HL1014/HL1004] (GTX500047)

Spike RBD ELISA Pair [HL1014 / HL1003]

Spike RBD ELISA Pair [HL1014 / HL1003] (GTX500046)

Spike ELISA Pair [1A9 / HL13402]

Spike ELISA Pair [1A9 / HL13402] (GTX500043)

 

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Highlighted Proteins 

SARS-CoV-2 (COVID-19) Spike (ECD) protein, His tag (active)

SARS-CoV-2 (COVID-19) Spike (ECD) protein, His tag (active)
(GTX135972-pro)

SARS-CoV-2 (COVID-19) Spike RBD (K417N, E484K, N501Y Mutant) protein, His tag (active)

SARS-CoV-2 (COVID-19) Spike RBD (K417N, E484K, N501Y Mutant) protein, His tag (active)
(GTX136022-pro)

SARS-CoV-2 (COVID-19) Spike RBD (N501Y Mutant) protein, His tag (active) 

SARS-CoV-2 (COVID-19) Spike RBD (N501Y Mutant) protein, His tag (active)
(GTX136014-pro)

SARS-CoV-2 (COVID-19) Spike RBD (N501Y Mutant) protein, His tag (active)

SARS-CoV-2 (COVID-19) Spike RBD (K417T, E484K, N501Y Mutant) protein, His tag (GTX136043-pro)

 

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