APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| Assay dependent |
| 3 μg/ml |
Not tested in other applications.
Calculated MW
Predict Reactivity
Rabbit, Bovine, Dog, Monkey, Bat, Chimpanzee, Gorilla, Horse, Marmoset, Orangutan, Panda(>80% identity)
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.1% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Synthetic 20 amino acid peptide from N-terminal extracellular domain of human 5HT2B Receptor.
Purification
Purified by affinity chromatography
Conjugation
Unconjugated
RRID
AB_375148
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
HTR2B , Serotonin receptor 2B , SR-2B , 5-hydroxytryptamine receptor 2B , 5HT(2B) , 5HT2B , 5hydroxytryptamine receptor 2B , 5HT2B Receptor , 5-HT2B receptor
Cellular Localization
Cell membrane,Cell junction, synapse, synaptosome
Background
This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]
Database
Research Area
DATA IMAGES
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GTX70503 IHC-P Image
IHC-P analysis of human brain, neurons and glia tissue using GTX70503 5-HT2B receptor antibody.
Antigen retrieval : Heat-induced antigen retrieval
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GTX70503 IHC-P Image
IHC-P analysis of brain, amygdala neurons tissue using GTX70503 5-HT2B receptor antibody.
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GTX70503 IHC-P Image
IHC-P analysis of human brain, glioblastoma tissue using GTX70503 5-HT2B receptor antibody.
Antigen retrieval : Heat-induced antigen retrieval
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GTX70503 IHC-P Image
IHC-P analysis of human lung, small cell carcinoma tissue using GTX70503 5-HT2B receptor antibody.
Antigen retrieval : Heat-induced antigen retrieval
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GTX70503 IHC-P Image
IHC-P analysis of brain, substantia nigra tissue using GTX70503 5-HT2B receptor antibody.
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REFERENCE
REVIEW
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