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ABCB4 antibody, Internal

Orthogonal
Anti-ABCB4 antibody, Internal used in Western Blot (WB). GTX47122
Anti-ABCB4 antibody, Internal used in Western Blot (WB). GTX47122
Anti-ABCB4 antibody, Internal used in Western Blot (WB). GTX47122

Cat. No. GTX47122

Reference 1

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB

Reactivity

 Human
Package
50 μg ($399)
See all ABCB4 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 0.2-2.5 ug/ml
Not tested in other applications.

Calculated MW

142 kDa. ( Note )

Positive Control

HT1080

PROPERTIES

Form

Liquid

Buffer

PBS, 2% Sucrose

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.5-1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

A synthetic peptide corresponding to an Internal region of Human ABCB4

Purification

Affinity Purified

Conjugation

Unconjugated

RRID

AB_11174805

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

ATP binding cassette subfamily B member 4 , ABC21 , GBD1 , ICP3 , MDR2 , MDR2/3 , MDR3 , PFIC-3 , PGY3

Cellular Localization

Cell membrane,Apical cell membrane,Cytoplasm

Background

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-ABCB4 antibody, Internal used in Western Blot (WB). GTX47122

GTX47122 WB Image

WB analysis of HT1080 cells using GTX47122 ABCB4 antibody at 0.2-1μg/ml.

Anti-ABCB4 antibody, Internal used in Western Blot (WB). GTX47122

GTX47122 WB Image

Orthogonal

The data was published in the journal J Exp Clin Cancer Res in 2018. PMID: 29743122

Anti-ABCB4 antibody, Internal used in Western Blot (WB). GTX47122

GTX47122 WB Image

The data was published in the journal J Exp Clin Cancer Res in 2018. PMID: 29743122

REFERENCE

Application Reference

Chen X et al. J Exp Clin Cancer Res 2018; 37 (1) : 100 SPIN1, negatively regulated by miR-148/152, enhances Adriamycin resistance via upregulating drug metabolizing enzymes and transporter in breast cancer.
Application : WB
Reactivity : Human
Submit a Reference

REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399