GeneTex

  • Country / Location Selection

United States (US)

ARMER antibody

Anti-ARMER antibody used in IHC (Paraffin sections) (IHC-P). GTX85516
Anti-ARMER antibody used in Western Blot (WB). GTX85516
Anti-ARMER antibody used in IHC (Paraffin sections) (IHC-P). GTX85516

Cat. No. GTX85516

Reference 4

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P, IHC-Fr, ELISA

Reactivity

 Human, Mouse, Rat
Package
100 μg ($399)
See all ARMER products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 0.5 - 2 μg/mL
IHC-P 2 μg/mL
IHC-Fr Assay dependent
ELISA Assay dependent
Not tested in other applications.

Calculated MW

23 kDa. ( Note )

Positive Control

Mouse Small Intestine Tissue Lysate(GTX27939)

Product Note

This antibody is specific for ARMER C-Terminus

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

ARMER antibody was raised against a peptide corresponding to 15 amino acids near the C-terminus of human ARMER.The immunogen is located within the last 50 amino acids of ARMER.

Purification

Purified by ion exchange chromatography

Conjugation

Unconjugated

RRID

AB_10721823

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

ADP ribosylation factor like GTPase 6 interacting protein 1 , AIP1 , ARL6IP , ARMER , SPG61

Cellular Localization

Endoplasmic reticulum membrane,Endoplasmic reticulum

Background

Apoptosis is important for normal development and tissue homeostasis. It is mediated by various caspases and ultimately results in the activation of endogenous endonucleases that degrade cellular DNA (1). Although apoptosis induced by endoplasmic reticulum (ER) stress is thought to be mediated by caspase-12 (2), other caspases such as caspase-9 are also thought to be activated following ER stress (3). Recently, ARMER, a novel integral ER-membrane protein was shown to protect cells from ER stress-induced apoptosis. Analysis of the caspase proteolytic cascade suggests that ARMER acts by inhibiting caspase-9 activity (3), although the mechanism for this remains unkown. It should be noted that ARMER is not related to the inhibitor of apoptosis proteins (IAP) family and does not contain any baculoviral IAP repeat (BIR) domains.

Database

Research Area

DATA IMAGES

Anti-ARMER antibody used in IHC (Paraffin sections) (IHC-P). GTX85516

GTX85516 IHC-P Image

IHC-P analysis of mouse intestine tissue using GTX85516 ARMER antibody.
Working concentration : 2 μg/ml

Anti-ARMER antibody used in Western Blot (WB). GTX85516

GTX85516 WB Image

WB analysis of mouse small intestine tissue lysate using GTX85516 ARMER antibody.
Working concentration : (A) 0.5, (B) 1, and (C) 2 μg/ml

Anti-ARMER antibody used in IHC (Paraffin sections) (IHC-P). GTX85516

GTX85516 IHC-P Image

IHC-P analysis of human bladder tissue using GTX85516 ARMER antibody.
Working concentration : 2 μg/ml

REFERENCE

Application Reference

Zhou GF et al. Proc Natl Acad Sci U S A 2023; 120 (22) : e2220148120 ARL6IP1 mediates small-molecule-induced alleviation of Alzheimer pathology through FXR1-dependent BACE1 translation initiation.
Dwayne J Byrne et al. Acta Neuropathol Commun 2022; 10 (1) : 40 Liver X receptor-agonist treatment rescues degeneration in a Drosophila model of hereditary spastic paraplegia.
Application : WB
Deng HS et al. Neurosci Lett 2019; 699 : 151-159 Proteomic profiling reveals Arl6ip-1 as a candidate target in cancer-induced bone pain rat model after * treatment.
Application : IHC-Fr
Reactivity : Rat
Dong R et al. J Cell Biol 2018; (Epub) The inositol 5-phosphatase INPP5K participates in the fine control of ER organization.
Application : WB
Reactivity : Human
Submit a Reference

REVIEW

There are currently no reviews for ARMER antibody (GTX85516). Be the first to share your experience with this product.
Submit a Review
SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399