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ATF1 antibody [ATF1 2A9/8]

Cat No. GTX18123

Host

Mouse

Clonality

Monoclonal

Clone Name

ATF1 2A9/8

Isotype

IgG2a

Application

WB, IP

Reactivity

Human
Package
100 μg ($339)

APPLICATION

Application Note

IP: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. Predicted molecular weight: 60 kDa. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

29 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS pH7.2

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.7 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

ATF1

Purification

IgG fraction

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

activating transcription factor 1 , EWS-ATF1 , FUS/ATF-1 , TREB36

Cellular Localization

Nucleus

Background

This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6. [provided by RefSeq, Aug 2010]

Database

Research Area

REFERENCE

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REVIEW

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Package List Price ($)
$ 339
Custom Conjugations