*Optimal dilutions/concentrations should be determined by the researcher.
Not tested in other applications.
HCT116 , HCT116 treated 1mM Hydroxyurea , Raji , Raji nuclear extract
1XPBS, 1% BSA, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
0.17mg/ml(Please refer to the vial label for the specific concentration.)
Carrier-protein conjugated synthetic peptide corresponding to residues around human ATR (phospho Thr1989). The exact sequence is proprietary.
Purified by antigen-affinity chromatography.
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
FRP1 antibody, MEC1 antibody, SCKL antibody, SCKL1 antibody, ATR antibody, FRAP-related protein 1 antibody, serine/threonine-protein kinase ATR antibody, ataxia telangiectasia and Rad3-related protein antibody, Rad3 related protein antibody, FRAP-related protein-1 antibody, MEC1, mitosis entry checkpoint 1, homolog antibody, protein kinase ATR antibody, ataxia telangiectasia and Rad3 related antibody
The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist. [provided by RefSeq]