GeneTex
United States (US)

Apolipoprotein E4 recombinant protein

ApoE4-recombinant-protein_WB_GTX65523-1_18121409_501.jpg

Cat No. GTX65523

Application WB, ELISA, Functional Assay, Apuri, Blocking
Reactivity Human
Species Human
APPLICATION

Calculated MW

34.4 kDa. ( Note )
PROPERTIES

Form

Lyophilized powder

Storage

Reconstitute in ddH2O. Store at -20ºC.

Antigen Species

Human

Expression System

E. coli

Purification


Purity was assessed by SDS-PAGE (≥90%) and by HPLC (≥90%).

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

AD2, LDLCQ5, LPG, MGC1571

Background

ApoE belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solublization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ. ApoE is an important constituent of all plasma lipoproteins. It’s interaction with specific ApoE receptor enables uptake of chylomicron remnants by liver cells, which is an essential step during normal lipid metabolism. It also binds with the LDL receptor (apo B/E). Defects in ApoE are a cause of hyperlipoproteinemia type III. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. Individuals heterozygous for the ApoE4 allele are at higher risk of late-onset Alzheimer’s disease. Recombinant human ApoE4 is a 34.4 kDa protein containing 300 amino acid residues (Accession No. AAB59397). This protein has a N-terminal His-tag.

Research Area

DATA IMAGES
ApoE4-recombinant-protein_WB_GTX65523-1_18121409_501.jpg

GTX65523 WB Image

Western blot analysis of ApoE4 using recombinant human ApoE4
Lane 1: 250 ng
Lane 2: 1 ug

Package List Price ($)
$ 199