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Aromatase antibody

Anti-Aromatase antibody used in Western Blot (WB). GTX18995

Cat. No. GTX18995

Reference 5

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IHC-P, IHC

Reactivity

 Human, Mouse, Rat, Rabbit, Bovine, Chicken, Pig, Horse
Package
50 μg ($399)
See all Aromatase products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 0.5-4 μg/ml
ICC/IF Assay dependent
IHC-P Assay dependent
IHC 10-20 μg/ml
Not tested in other applications.

Calculated MW

58 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS pH7.2, 30% Glycerol, 0.5% BSA, 5mM EDTA

Preservative

0.03% ProClin

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.5 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide surrounding amino acid 385 of human Aromatase

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

RRID

AB_510151

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

cytochrome P450 family 19 subfamily A member 1 , ARO , ARO1 , CPV1 , CYAR , CYP19 , CYPXIX , P-450AROM

Background

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016]

Database

Research Area

DATA IMAGES

Anti-Aromatase antibody used in Western Blot (WB). GTX18995

GTX18995 WB Image

WB analysis of human brain lysate using GTX18995 Aromatase antibody.

REFERENCE

Application Reference

R Hu et al. J Ethnopharmacol 2023; : 117654 Jiawei Buzhong Yiqi decoction ameliorates polycystic ovary syndrome via oocyte-granulosa cell communication
Application : WB
He Z et al. Int J Mol Sci 2023; 24 (18) FoxH1 Represses the Promoter Activity of cyp19a1a in the Ricefield Eel (Monopterus albus).
Wang Z et al. Phytomedicine 2021; 91 : 153654 Berberine improves ovulation and endometrial receptivity in polycystic ovary syndrome.
Application : IHC-P
Reactivity : Rat
Kobayashi H et al. Exp Anim 2020; (Epub) Estrogen synthesis in the stomach of Sprague-Dawley rats: comparison to Wistar rats.
Application : ICC/IF
Reactivity : Rat
Nurliani A et al. J Vet Med Sci 2019; An immunohistochemical study on testicular steroidogenesis in the Sunda porcupine (Hystrix javanica).
Application : IHC-P
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SDS
PBS.pdf
Glycerol.pdf
Proclin.pdf
Package List Price ($)
$ 399