APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1:500 - 1:2000 |
| 1:50 - 1:200 |
Not tested in other applications.
Calculated MW
PROPERTIES
Form
Liquid
Buffer
PBS, 50% Glycerol
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 300-400 of human ARRB2 (NP_004304.1).
Purification
Purified by affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
arrestin beta 2 , ARB2 , ARR2 , BARR2
Cellular Localization
Cytoplasm,Nucleus,Cell membrane,Cytoplasmic vesicle
Background
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
Database
Research Area
DATA IMAGES
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GTX64830 ICC/IF Image
ICC/IF analysis of NIH/3T3 cells using GTX64830 Beta Arrestin 2 antibody.
Blue : DAPI
Dilution : 1:100
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GTX64830 ICC/IF Image
ICC/IF analysis of C6 cells using GTX64830 Beta Arrestin 2 antibody.
Blue : DAPI
Dilution : 1:100
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GTX64830 WB Image
WB analysis of various sample lysates using GTX64830 Beta Arrestin 2 antibody. The signal was developed with ECL plus-Enhanced.
Dilution : 1:1000
Loading : 25μg per lane
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GTX64830 ICC/IF Image
ICC/IF analysis of HeLa cells using GTX64830 Beta Arrestin 2 antibody.
Blue : DAPI
Dilution : 1:100
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REFERENCE
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REVIEW
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