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CASPR antibody

Anti-CASPR antibody used in Western Blot (WB). GTX133272
Anti-CASPR antibody used in IHC (Paraffin sections) (IHC-P). GTX133272
Anti-CASPR antibody used in IHC (Paraffin sections) (IHC-P). GTX133272

Cat. No. GTX133272

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P

Reactivity

 Mouse, Rat
Package
100 μl ($399),
25 μl ($169)
See all CASPR products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500-1:3000
IHC-P 1:100-1:1000
Not tested in other applications.

Calculated MW

156 kDa. ( Note )

Positive Control

mouse brain , rat brain

Predict Reactivity

Rhesus Monkey(>80% identity)

PROPERTIES

Form

Liquid

Buffer

PBS, 20% Glycerol

Preservative

0.025% ProClin 300

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.53 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Mouse

Immunogen

Recombinant protein encompassing a sequence within the Intracellular domain of mouse CASPR. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

RRID

AB_2886902

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

contactin associated protein-like 1 , AI841080 , Caspr , NCP1 , Nrxn4 , p190 , shm

Cellular Localization

Membrane

Background

Seems to play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the paranodal region of the axo-glial junction. In association with contactin may have a role in the signaling between axons and myelinating glial cells. Mice that lack CNTAP1 exhibit tremor, ataxia, and significant motor paresis. Normal paranodal junctions fail to form, and the organization of the paranodal loops is disrupted. Contactin is undetectable in the paranodes, and potassium channels are displaced from the juxtaparanodal into the paranodal domains. Also results in a severe decrease in peripheral nerve conduction velocity.

Database

Research Area

DATA IMAGES

Anti-CASPR antibody used in Western Blot (WB). GTX133272

GTX133272 WB Image

Various tissue extracts (75 μg) were separated by 5% SDS-PAGE, and the membrane was blotted with Caspr1 antibody (GTX133272) diluted at 1:1000.

Anti-CASPR antibody used in IHC (Paraffin sections) (IHC-P). GTX133272

GTX133272 IHC-P Image

CASPR antibody detects CASPR protein at cell membrane and cytoplasm in rat brain by immunohistochemical analysis.
Sample: Paraffin-embedded rat brain.
CASPR antibody (GTX133272) diluted at 1:1000.

Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-CASPR antibody used in IHC (Paraffin sections) (IHC-P). GTX133272

GTX133272 IHC-P Image

CASPR antibody detects CASPR protein at cell membrane and cytoplasm in mouse brain by immunohistochemical analysis.
Sample: Paraffin-embedded mouse brain.
CASPR antibody (GTX133272) diluted at 1:1000.

Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

REFERENCE

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REVIEW

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SDS
PBS.pdf
Glycerol.pdf
Proclin.pdf
Package List Price ($)
$ 399
$ 169