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CD3 epsilon antibody [UCHT1]

Cat. No. GTX14593

Reference 1

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 UCHT1

Isotype

 IgG1

Application

 FACS, Activation, Depletion, Neutralizing/Inhibition

Reactivity

 Human
Package
500 μg ($319)
See all CD3 epsilon products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
FACS Assay dependent
Activation Assay dependent
Depletion Assay dependent
Neutralizing/Inhibition Assay dependent

Note :

Activation
Crosslinking of the TCR via immobilized UCHT1 (Leu-4)(T3) antibody is commonly used to activate T cells in vitro.

Depletion
n vivo T cell depletion in humanized mice

Neutralizing/Inhibition
ex vivo T cell inhibition for xenograph
Not tested in other applications.

Calculated MW

23 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Filter-sterilized PBS

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Human CD3ε

Purification

Protein G purified
From tissue culture supernatant

Purity

>95% (Determined by SDS-PAGE)

Endotoxin

< 0.002 EU/弮g (Determined by LAL assay)

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CD3E,CD3e molecule,IMD18,T3E,TCRE,CD3 epsilon

Cellular Localization

Membrane

Background

The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]

Database

Research Area

REFERENCE

Clone Reference

Yarbrough WM et al. Circulation 2003; 108 (14):1753-9 Selective targeting and timing of matrix metalloproteinase inhibition in post-myocardial infarction remodeling.
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REVIEW

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Package List Price ($)
$ 319