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CD31 antibody [WM59]

Cat. No. GTX20218

Reference 25

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 WM59

Isotype

 IgG1

Application

 ICC/IF, IHC-Fr, IHC-Wm, FACS, IP, IHC

Reactivity

 Human, Mouse, Rabbit, Cynomolgus monkey, Rhesus Monkey
Package
100 μg ($399)
See all CD31 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
ICC/IF Assay dependent
IHC-Fr Assay dependent
IHC-Wm Assay dependent
FACS 1/50-1/100
IP Assay dependent
IHC Assay dependent

Note :

FACS
Use 10μl of the suggested working dilution to label 106 cells in 100μl.

IHC
Not recommended for immunohistochemical staining of formalin-fixed paraffin-embedded sections.
Not tested in other applications.

Calculated MW

83 kDa. ( Note )

Product Note

The binding epitope for mouse anti human CD31, clone WM59 has been mapped to the Ig-like domain 2 (Fawcett et al. 1995).

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1.0 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Purification

Protein G purified
From tissue culture supernatant

Conjugation

Unconjugated

RRID

AB_372688

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

platelet and endothelial cell adhesion molecule 1 , CD31 , CD31/EndoCAM , GPIIA' , PECA1 , PECAM-1 , endoCAM

Cellular Localization

Cell membrane , Cell junction

Background

The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. [provided by RefSeq, May 2010]

Database

Research Area

REFERENCE

Application Reference

D Livkisa et al. Biomaterials 2024; 306 : 122502 Extracellular vesicles purified from serum-converted human platelet lysates offer strong protection after cardiac ischaemia/reperfusion injury
N Gu et al. Research Square 2023; Prevotella copri transplantation promotes neurorehabilitation in a mouse model of traumatic brain injury through the GUO-PI3K/Akt signaling pathway
Application : IHC-Fr
Fei Sun et al. Bioeng Transl Med. 2023; : e10534 Biomimetic in situ tracheal microvascularization for segmental tracheal reconstruction in one-step
Application : ICC/IF
Reactivity : Rabbit
Yan J et al. J Neuroinflammation 2022; 19 (1) : 289 TREM2 activation alleviates neural damage via Akt/CREB/BDNF signalling after traumatic brain injury in mice.
Xuehui Fan et al. Front Pharmacol 2022; 13 : 834948 S1PR3, as a Core Protein Related to Ischemic Stroke, is Involved in the Regulation of Blood-Brain Barrier Damage.
Reactivity : Mouse
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REVIEW

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Application Reference
D Livkisa et al. Biomaterials 2024; 306:122502 Extracellular vesicles purified from serum-converted human platelet lysates offer strong protection after cardiac ischaemia/reperfusion injury
N Gu et al. Research Square 2023; Prevotella copri transplantation promotes neurorehabilitation in a mouse model of traumatic brain injury through the GUO-PI3K/Akt signaling pathway
Application : IHC-Fr
Fei Sun et al. Bioeng Transl Med. 2023;:e10534 Biomimetic in situ tracheal microvascularization for segmental tracheal reconstruction in one-step
Application : ICC/IF
Reactivity : Rabbit
Yan J et al. J Neuroinflammation 2022; 19 (1):289 TREM2 activation alleviates neural damage via Akt/CREB/BDNF signalling after traumatic brain injury in mice.
Xiaopeng Guo et al. Oxid Med Cell Longev 2022; 2022:7541411 Reducing the Damage of Ox-LDL/LOX-1 Pathway to Vascular Endothelial Barrier Can Inhibit Atherosclerosis.
Xuehui Fan et al. Front Pharmacol 2022; 13:834948 S1PR3, as a Core Protein Related to Ischemic Stroke, is Involved in the Regulation of Blood-Brain Barrier Damage.
Reactivity : Mouse
Wang Z et al. Cell Biol Int 2021; (Epub) Exosomal microRNA-1246 from human umbilical cord mesenchymal stem cells potentiates myocardial angiogenesis in chronic heart failure.
Xu H et al. Stem Cells Transl Med 2021; 10 (5):781-796 Cotransplantation of mesenchymal stem cells and endothelial progenitor cells for treating steroid-induced osteonecrosis of the femoral head.
Application : FACS
Reactivity : Rabbit
Choo SY et al. Int J Oncol 2019; 54 (4):1327-1336 Runx3 inhibits endothelial progenitor cell differentiation and function via suppression of HIF-1α activity.
Application : FACS
Reactivity : Mouse
Chen J et al. Acta Biomater 2018; 80:154-168 Chitosan/silk fibroin modified nanofibrous patches with mesenchymal stem cells prevent heart remodeling post-myocardial infarction in rats.
Reactivity : Mouse
B. Glueck et al. Journal of Immunology Research 2018; 2018:9671919 Tributyrin Supplementation Protects Immune Responses and Vasculature and Reduces Oxidative Stress in the Proximal Colon of Mice Exposed to Chronic-Binge Ethanol Feeding.
Application : IHC-Fr
Reactivity : Mouse
Ou Y et al. Int J Clin Exp Pathol 2018; 11 (6):3052-3060 Silencing profilin-1 confers protection from oxLDL injury in human vascular endothelial cells.
Application : ICC/IF
Reactivity : Human
Lee HY et al. Oncotarget 2018; 9 (17):13193-13205 EIF3C-enhanced exosome secretion promotes angiogenesis and tumorigenesis of human hepatocellular carcinoma.
Reactivity : Mouse
Chen PS et al. Sci Rep 2017; 7 (1):3284 Recombinant Thrombomodulin Exerts Anti-autophagic Action in Endothelial Cells and Provides Anti-atherosclerosis Effect in Apolipoprotein E Deficient Mice.
Hsu PY et al. J Cell Mol Med 2016; (Epub) MicroRNA let-7g possesses a therapeutic potential for peripheral artery disease.
Reactivity : Mouse
Aldahmash A et al. Saudi J Biol Sci 2016; (Epub) Transplantation of human neonatal foreskin stromal cells in ex vivo organotypic cultures of embryonic chick femurs.
Reactivity : Human
Kilarski WW et al. Angiogenesis 2014; 17 (2):347-57 Optimization and regeneration kinetics of lymphatic-specific photodynamic therapy in the mouse dermis.
Application : IHC-Wm
Reactivity : Mouse
Chen YJ et al. Gynecol Oncol 2013; 131 (3):734-43 The synthetic flavonoid WYC02-9 inhibits cervical cancer cell migration/invasion and angiogenesis via MAPK14 signaling.
Application : IHC
Reactivity : Human
Kanczler JM et al. Tissue Eng Part C Methods 2012; 18 (10):747-60 A novel approach for studying the temporal modulation of embryonic skeletal development using organotypic bone cultures and microcomputed tomography.
Daussin FN et al. Am J Physiol Regul Integr Comp Physiol 2008; 295 (1):R264-72 Effect of interval versus continuous training on cardiorespiratory and mitochondrial functions: relationship to aerobic performance improvements in sedentary subjects.
Application : IHC
Reactivity : Human
Breslin JW et al. Lymphat Res Biol 2007; 5 (2):105-13 VEGF-C alters barrier function of cultured lymphatic endothelial cells through a VEGFR-3-dependent mechanism.
Application : ICC/IF
Reactivity : Human
Clone Reference
Trivedi A et al. J Transl Med 2019; 17 (1):128 Bone marrow donor selection and characterization of MSCs is critical for pre-clinical and clinical cell dose production.
Liu YW et al. Int J Cardiol 2013; 168 (1):66-75 Xenografted human amniotic fluid-derived stem cell as a cell source in therapeutic angiogenesis.
Wang Y et al. Am J Physiol Gastrointest Liver Physiol. 2012; 303 (11):G1236-44 Maternofetal and neonatal copper requirements revealed by enterocyte-specific deletion of the Menkes disease protein.
Application : IHC-Fr
Reactivity : Mouse
Shi Q et al. Gene Ther 2010; 17 (9):1085-97 A combinatorial approach for targeted delivery using small molecules and reversible masking to bypass nonspecific uptake in vivo.
Application : FACS
Reactivity : Human
SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399