APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1:100-2000 |
| 1:100-800 (based on 0.5 mg/ml) |
Not tested in other applications.
Calculated MW
PROPERTIES
Form
Liquid
Buffer
10mM PBS
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
0.5 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
KLH conjugated synthetic peptide derived from human CD35.
Purification
Purified by antigen-affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
complement C3b/C4b receptor 1 (Knops blood group) , C3BR , C4BR , CD35 , KN
Cellular Localization
Membrane
Background
This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. [provided by RefSeq, Jul 2008]
Database
Research Area
DATA IMAGES
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GTX37450 WB Image
WB analysis of rat pancreas (Lane 1), rat thymus (Lane 2), human breast cancer (Lane 3) tissue lysates using GTX37450 CD35 antibody.
Dilution : 1μg/ml
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GTX37450 IHC-P Image
IHC-P analysis of mouse lymph node tissue using GTX37450 CD35 antibody.
Dilution : 2.5μg/ml
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GTX37450 IHC-P Image
IHC-P analysis of human endometrial cancer tissue using GTX37450 CD35 antibody.
Dilution : 2.5μg/ml
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GTX37450 IHC-P Image
IHC-P analysis of rat stomach tissue using GTX37450 CD35 antibody.
Dilution : 2.5μg/ml
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REFERENCE
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REVIEW
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