GeneTex
United States (US)

CD40 antibody [HI40a]

GTX15018_CD40-antibody-HI40a__GTX15018-1_19012723_767.jpeg

Cat No. GTX15018

Host Mouse
Clonality Monoclonal
Clone Name HI40a
Isotype IgG1
Application FACS
Reactivity Human
APPLICATION

Application Note

FACS: The purified antibody is effective for indirect immunofluorescence staining of human cells by flow cytometry analysis using 0.25 mg/test Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

31 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

Preservative: NoneConstituents: PBS

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Full length native protein (purified) (Human).

Purification

Protein G purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Cd40 Molecule,Bp50,Cdw40,Tnfrsf5,P50,Cd40

Cellular Localization

Type I membrane protein (isoforms I, III, IV and V); secreted (isoform II).

Background

CD40 (48-50 kDa) is a transmembrane glycoprotein mainly expressed on the surface of B cells and also expressed on monocytes, dendritic cells, and thymic epithelium. CD40 is a member of the tumor necrosis factor (TNF) receptor superfamily, which includes the low affinity nerve growth factor (NGF) receptor and CD95/Fas. CD40 is the receptor for CD40 ligand. CD40 ligand (CD40L, CD154, gp39, and TRAM) belongs to the TNF gene family and is expressed more widely than CD40 predominantly on activated CD4+ T cells. Following interaction with CD40 ligand, CD40 mediates a number of major immunoregulatory functions, central to the control of thymus-dependent humoral immunity and may be critical in the development of cell-mediated immune responses. Other biological actions include B cell homotypic adhesion, proliferation, immunoglobulin isotype switch, and secretion. Activation of CD40 has also been shown to inhibit the growth of certain B cell lymphomas and to induce the death of transformed cells of mesenchymal or epithelial origin.

Database

Research Area

DATA IMAGES
GTX15018_CD40-antibody-HI40a__GTX15018-1_19012723_767.jpeg

GTX15018 FACS Image

Surface staining of human peripheral blood cells with anti-human CD40: FITC (GTX80131). Cells in the lymphocyte gate were used for analysis.

Package List Price ($)
$ 319