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CLCN7 antibody

Anti-CLCN7 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX55139
Anti-CLCN7 antibody used in Western Blot (WB). GTX55139

Cat. No. GTX55139

Reference 1

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF

Reactivity

 Human, Mouse, Rat
Package
100 μl ($399)
See all CLCN7 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500 - 1:1000
ICC/IF 1:100 - 1:500
Not tested in other applications.

Calculated MW

89 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

0.42% Potassium Phosphate, 0.87% NaCl, 30% Glycerol

Preservative

0.01% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of CLCN7. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

chloride voltage-gated channel 7 , CLC-7 , CLC7 , OPTA2 , OPTB4 , PPP1R63

Cellular Localization

Lysosome membrane

Background

The product of this gene belongs to the CLC chloride channel family of proteins. Chloride channels play important roles in the plasma membrane and in intracellular organelles. This gene encodes chloride channel 7. Defects in this gene are the cause of osteopetrosis autosomal recessive type 4 (OPTB4), also called infantile malignant osteopetrosis type 2 as well as the cause of autosomal dominant osteopetrosis type 2 (OPTA2), also called autosomal dominant Albers-Schonberg disease or marble disease autosoml dominant. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. OPTA2 is the most common form of osteopetrosis, occurring in adolescence or adulthood. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-CLCN7 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX55139

GTX55139 ICC/IF Image

ICC/IF analysis of formalin-fixed HeLa cells using GTX55139 CLCN7 antibody.
Red : Primary antibody
Blue : DAPI
Permeabilization : 0.1% Triton X-100 in TBS for 5-10 minutes

Anti-CLCN7 antibody used in Western Blot (WB). GTX55139

GTX55139 WB Image

WB analysis of HeLa (A), mouse liver (B), rat liver (C) whole cell lysates using GTX55139 CLCN7 antibody.

REFERENCE

Application Reference

Lin J et al. Mol Med Rep 2021; 23 (3) H(+)/Cl(?) exchange transporter 7 promotes lysosomal acidification?mediated autophagy in mouse cardiomyocytes.
Application : WB
Reactivity : Mouse
Submit a Reference

REVIEW

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SDS
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399