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CRK antibody

Anti-CRK antibody used in IHC (Paraffin sections) (IHC-P). GTX78919

Cat. No. GTX78919

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 IHC-P

Reactivity

 Human
Package
100 μg ($399)
See all CRK products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1:50 - 1:100
Not tested in other applications.

Calculated MW

34 kDa. ( Note )

Product Note

This antibody was raised against CRK2 protein, and it may not recognize CRK1 protein.

PROPERTIES

Form

Liquid

Buffer

PBS (without Mg²⁺ and Ca²⁺) pH7.4, 150mM NaCl, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

The antiserum was produced against synthesized non-phosphopeptide derived from human Crk2 around the phosphorylation site of tyrosine 221.

Purification

Purified by antigen-affinity chromatography
From serum

Conjugation

Unconjugated

RRID

AB_11178649

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CRK,CRK protooncogene, adaptor protein,CRKII,p38,CRK II,CRK2,Crk p38,CRK proto-oncogene, adaptor protein

Cellular Localization

Cytoplasm,Cell membrane

Background

This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-CRK antibody used in IHC (Paraffin sections) (IHC-P). GTX78919

GTX78919 IHC-P Image

IHC-P analysis of human lung adenocarcinoma tissue using GTX78919 CRK antibody.

REFERENCE

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REVIEW

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Package List Price ($)
$ 399