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CTLA4 antibody [UC10-4F10-11]

Anti-CTLA4 antibody [UC10-4F10-11] used in Western Blot (WB). GTX13996

Cat. No. GTX13996

Host

 Armenian Hamster

Clonality

 Monoclonal

Clone Name

 UC10-4F10-11

Isotype

 IgG1

Application

 WB, FACS, Activation, Neutralizing/Inhibition

Reactivity

 Mouse
Package
500 μg ($399)
See all CTLA4 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
FACS Assay dependent
Activation Assay dependent
Neutralizing/Inhibition Assay dependent

Note :

Activation
The UC10-4F10-11 antibody has been shown to promote T cell co-stimulation by blocking CTLA-4 binding to the B7 co-receptors, allowing for CD28 binding.
Not tested in other applications.

Calculated MW

25 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Filter-sterilized PBS

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Mouse

Immunogen

Mouse CTLA-4 IgG2a fusion protein

Purification

Protein G purified
From tissue culture supernatant

Purity

>95% (Determined by SDS-PAGE)

Endotoxin

< 0.002 EU/弮g (Determined by LAL assay)

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Cellular Localization

Cell membrane

Background

This gene is a member of the immunoglobulin superfamily, and encodes a protein that functions as a negative regulator of T-cell responses. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2013]

Database

Research Area

DATA IMAGES

Anti-CTLA4 antibody [UC10-4F10-11] used in Western Blot (WB). GTX13996

GTX13996 WB Image

WB analysis of purified CTLA4 recombinant protein using GTX13996 CTLA4 antibody [UC10-4F10-11].
Lane 1 : 1 ug reduced purified mouse CTLA-4 with histidine tag 0.5 ug reduced purified mouse
Dilution : 15 ug/ml

REFERENCE

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REVIEW

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Package List Price ($)
$ 399