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CXXC4 antibody

Anti-CXXC4 antibody used in Western Blot (WB). GTX84996
Anti-CXXC4 antibody used in IHC (Paraffin sections) (IHC-P). GTX84996
Anti-CXXC4 antibody used in IHC (Paraffin sections) (IHC-P). GTX84996

Cat. No. GTX84996

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P, ELISA

Reactivity

 Human, Mouse, Rat
Package
100 μg ($399)
See all CXXC4 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1 μg/mL
IHC-P 10 μg/mL
ELISA Assay dependent
Not tested in other applications.

Positive Control

Human Brain Tissue Slide(GTX22203) , Human Brain Tissue Lysate(GTX27918)

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

CXXC4 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human CXXC4.The immunogen is located within amino acids 50 - 100 of CXXC4.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CXXC finger protein 4 , IDAX

Background

CXXC4 is zinc finger protein that binds directly to the PDZ domain of DVL1, a protein involved in the Wnt signaling pathway, through its C-terminal region. CXXC4’s interaction with DVL1 competes with DVL1-AXIN binding, although the affinity of DVL1 for CXXC4 is lower than that for AXIN. In mouse fibroblasts, CXXC4 suppressed Wnt3a induction of beta-catenin and inhibited Wnt3a-dependent TCF4 activation, suggesting that CXXC4 acts as a negative regulator of the Wnt signaling pathway and functions between DVL and beta-catenin. Recent reports suggest that decreased CXXC4 expression is associated with kidney cancer metastasis, cell proliferation, reduced apoptosis in response to cancer drugs, and upregulation of genes involved with proliferation, invasion and cell survival, suggesting that CXXC4 plays a critical role in tumor progression in kidney cancer.

Database

Research Area

DATA IMAGES

Anti-CXXC4 antibody used in Western Blot (WB). GTX84996

GTX84996 WB Image

WB analysis of human brain tissue lysate in (A) the absence and (B) the presence of blocking peptide using GTX84996 CXXC4 antibody.
Working concentration : 1 μg/ml

Anti-CXXC4 antibody used in IHC (Paraffin sections) (IHC-P). GTX84996

GTX84996 IHC-P Image

IHC-P analysis of human brain tissue using GTX84996 CXXC4 antibody.
Working concentration : 20 μg/ml

Anti-CXXC4 antibody used in IHC (Paraffin sections) (IHC-P). GTX84996

GTX84996 IHC-P Image

IHC-P analysis of human brain tissue using GTX84996 CXXC4 antibody.
Working concentration : 10 μg/ml

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399