GeneTex
United States (US)

Caspase 3 peptide

Cat No. GTX27990

Application Blocking
Reactivity Human
Species Human
APPLICATION

Application Note

Blocking peptide for Rabbit polyclonal to Caspase 3 (GTX27980)
PROPERTIES

Form

Liquid

Buffer

PBS with 100ug BSA 0.1% sodium azide

Storage

Keep as concentrated solution, aliquot and store at 4ºC.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Caspase 3,Cpp32,Cpp32B,Sca-1,Casp3

Background

The caspase family of cysteine proteases play a key role in apoptosis. Caspase 3 (also known as CPP32, YAMA and apopain) is the most extensively studied apoptotic protein among caspase family members. Caspase 3 is synthesized as inactive pro-enzyme that is processed in cells undergoing apoptosis by self-proteolysis and/or cleavage by other upstream proteases (e.g. caspases 8, 9 and 10). The processed form of caspase 3 consists of large (17kD) and small (12kD) subunits which associate to form an active enzyme. Caspase 3 is cleaved at Asp28 - Ser29 and Asp175 - Ser176. The active caspase 3 proteolytically cleaves and activates other caspases (e.g. caspases 6, 7 and 9), as well as relevant targets in the cells (e.g. PARP and DFF).

Research Area