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Collagen II antibody [CIIC1]

Cat. No. GTX54398

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 CIIC1

Isotype

 IgG2a

Application

 IHC-P, IHC-Fr, ELISA, Functional Assay

Reactivity

 Mouse, Rat, Chicken, Baboon, Horse
Package
50 μg ($399)
See all Collagen II products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P Assay dependent
IHC-Fr Assay dependent
ELISA Assay dependent
Functional Assay Assay dependent

Note :

ELISA
This antibody is useful in immunoassays as coating and detection.
Not tested in other applications.

Calculated MW

142 kDa. ( Note )

Product Note

The monoclonal antibody CIICI reacts with the C1 epitope (triple helical position 358-364) of collagen type II. The monocolonal antibody CIIC1 has been shown to induce CAIA in naïve mice after injection of lipopolysacharide (LPS). However, in combination with the monoclonal antibody M2139, binding to the J1 epitope of CII, the pair of monoclonal antibodies induce arthritis in different strains of mice without any other stimulants. The presence of secondary stimulus, LPS, increases the disease incidence and severity.

PROPERTIES

Form

Liquid

Buffer

Filter-sterilized PBS, 0.1% BSA

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

100 μg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Mouse

Purification

Purified IgG2a

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

collagen, type II, alpha 1 , Col2 , Col2a , Col2a-1 , Del1 , Dmm , Lpk , M100413 , Rgsc413 , Rgsc856

Background

This gene encodes the alpha-1 subunit of the fibril-forming type II collagen, the major component of cartilage and the vitreous humor of the eye. The encoded preproprotein forms homotrimeric, triple helical procollagen that undergoes proteolytic processing during fibirl formation. Mice harboring certain mutations in this gene exhibit severe chondrodysplasia characterized by short limbs and trunch, craniofacial deformities and cleft palate. A complete lack of the encoded protein in mice results in postnatal lethality. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Dec 2015]

Database

Research Area

REFERENCE

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REVIEW

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Package List Price ($)
$ 399