Keep as concentrated solution. For extended storage add 50% glycerol, aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.
Purified by conventional chromatography.
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
DCTN-22, DCTN22, MGC111190, DCTN3, "dynactin 3, isoform 1", dynactin complex subunit 22 kDa subunit, p22, dynactin light chain, dynactin subunit 3, dynactin 3 (p22)
This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq]