GeneTex
United States (US)

DCTN3 Protein

GTX115607-pro_18121410_868.jpg

Cat No. GTX115607-pro

Application WB
Reactivity Human
Species Human
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB Assay dependent
Not tested in other applications.

Calculated MW

19 kDa. ( Note )
PROPERTIES

Buffer

0.1%SDS/PBS

Storage

Keep as concentrated solution. For extended storage add 50% glycerol, aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.

Expression System

E. coli

Purification

Purified by conventional chromatography.

Purity

95%

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

DCTN-22, DCTN22, MGC111190, DCTN3, "dynactin 3, isoform 1", dynactin complex subunit 22 kDa subunit, p22, dynactin light chain, dynactin subunit 3, dynactin 3 (p22)

Background

This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq]
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Research Area

DATA IMAGES
GTX115607-pro_18121410_868.jpg

GTX115607-pro WB Image

10ug of GTX115607-pro DCTN3 recombinant protein analyzed using SDS-PAGE and stained with coomassie blue and captured by black and white camera.