Elastin antibody

Name: Elastin antibody
Brand: GeneTex
SKU: GTX37428
Price: 399.00 USD
Rating: 5 (1 reviews)

Anti-Elastin antibody used in Western Blot (WB). GTX37428

Anti-Elastin antibody used in IHC (Paraffin sections) (IHC-P). GTX37428

Anti-Elastin antibody used in IHC (Frozen sections) (IHC-Fr). GTX37428

Cat. No. GTX37428

Reference 3

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	WB, IHC-P, IHC-Fr
Reactivity	Human, Mouse, Rat
Package	100 μg ($399)

See all Elastin products

View product citations for antibody GTX37428 on CiteAb

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Recommended Dilution
WB	Assay dependent
IHC-P	1:100-500
IHC-Fr	Assay dependent

Not tested in other applications.

Calculated MW

68 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

10mM PBS, 10mg/ml BSA

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.5 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

KLH conjugated synthetic peptide derived from human Elastin.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

RRID

AB_11175169

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

elastin , ADCL1 , SVAS , WBS , WS

Background

This gene encodes a protein that is one of the two components of elastic fibers. Elastic fibers comprise part of the extracellular matrix and confer elasticity to organs and tissues including the heart, skin, lungs, ligaments, and blood vessels. The encoded protein is rich in hydrophobic amino acids such as glycine and proline, which form mobile hydrophobic regions bounded by crosslinks between lysine residues. Degradation products of the encoded protein, known as elastin-derived peptides or elastokines, bind the elastin receptor complex and other receptors and stimulate migration and proliferation of monocytes and skin fibroblasts. Elastokines can also contribute to cancer progression. Deletions and mutations in this gene are associated with supravalvular aortic stenosis (SVAS) and autosomal dominant cutis laxa. [provided by RefSeq, Aug 2017]

Database

Gene ID: 2006 ELN
UniProt: P15502 ELN

Research Area

DATA IMAGES

GTX37428 WB Image

WB analysis of mouse spinal cord (Lane 1), rat bladder (Lane 2), mouse stomach (Lane 3), rat lung (Lane 4), rat testis (Lane 5) tissue lysates using GTX37428 Elastin antibody.
Dilution : 1μg/ml

GTX37428 IHC-P Image

IHC-P analysis of rat spinal cord tissue using GTX37428 Elastin antibody.
Dilution : 2.5μg/ml

GTX37428 IHC-P Image

IHC-P analysis of mouse stomach tissue using GTX37428 Elastin antibody.
Dilution : 2.5μg/ml

GTX37428 IHC-P Image

IHC-P analysis of mouse kidney tissue using GTX37428 Elastin antibody.
Dilution : 1:100

GTX37428 IHC-Fr Image

IHC-Fr analysis of mouse skin tissue using GTX37428 Elastin antibody.
Dilution : 1:100

REFERENCE

Application Reference

Lee TH et al. Nat Commun 2020; 11 (1) : 4254 Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFβ signaling through TGFBR1 stabilization.

Application : WB

Reactivity : Human

Honig J et al. RNA 2018; (Epub) Transmission of microRNA antimiRs to mouse offspring via the maternal-placental-fetal unit.

Application : WB

Shih YC et al. Circ Res 2018; (Epub) Endoplasmic Reticulum Protein TXNDC5 Augments Myocardial Fibrosis by Facilitating Extracellular Matrix Protein Folding and Redox-Sensitive Cardiac Fibroblast Activation.

Application : WB

Reactivity : Human

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