GeneTex
United States (US)

Endostatin recombinant protein

Cat No. GTX65524

Application ELISA, Functional Assay, Apuri, Blocking
Reactivity Human
Species Human
APPLICATION

Application Note

GeneTex' s human Endostatin is biologically active when compared to standards. The activity as calculated by ECE migration inhibition was found to be 50,000 IU/mg.

Calculated MW

20.0 kDa. ( Note )
PROPERTIES

Form

Liquid

Storage

Store at -20ºC. Product is stable for at least 12 months.

Antigen Species

Human

Expression System

Pichia Pastoria

Purification


Purity was assessed by SDS-PAGE (≥98%) and by HPLC (≥98%).

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

FLJ27325, FLJ34914, KNO, KNO1, KS, MGC74745

Background

Endostatin has been identified as a C-terminal fragment of Collagen type 18, a recently identified member of a family of collagen-like proteins referred to as multiplexin family Endostatin specifically inhibits proliferation of endothelial cells although it does not affect the proliferation of EOMA cells. Endostatin also potently inhibits angiogenesis and tumor growth. Endostatin has an important role in endothelial cell adhesion and cytoskeletal organization. Endostatin can be found in vessel walls (elastic fibers) and basement membranes. Recombinant Endosatin expressed in yeast causes G1 arrest of endothelial cells, and endostatin treatment results in apoptosis of HUVE and HMVE cells.

Research Area

Package List Price ($)
$ 249